ArticlePloS one2008
Modulation of NKT cell development by B7-CD28 interaction: an expanding horizon for costimulation.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 27 citations in OpenAlex.
- ZFP90 Serves as a Transcriptional Brake on NF-κB Signaling to Attenuate Diet-Induced MASLD Progression.Nutrients · 2026Article
- The RNA- and DNA-Binding Protein Y-Box Binding Protein 1 (YB-1) Regulates iNKT Cell Development.European journal of immunology · 2026Article
- The bidirectional immune crosstalk in metabolic dysfunction-associated steatotic liver disease.Cell metabolism · 2023Review
- Antigen-presenting T cells provide critical B7 co-stimulation for thymic iNKT cell development via CD28-dependent trogocytosis.Cell reports · 2022Article
- Thymic resident NKT cell subsets show differential requirements for CD28 co-stimulation during antigenic activation.Scientific reports · 2020Article
- The CD28 Transmembrane Domain Contains an Essential Dimerization Motif.Frontiers in immunology · 2020Article
- The ins and outs of type I iNKT cell development.Molecular immunology · 2019Review
- Mixed Signals: Co-Stimulation in Invariant Natural Killer T Cell-Mediated Cancer Immunotherapy.Frontiers in immunology · 2017Review
- CD28-CD80/86 and CD40-CD40L Interactions Promote Thymic Tolerance by Regulating Medullary Epithelial Cell and Thymocyte Development.Critical reviews in immunology · 2015Review
- Effects of costimulation on intrahepatic immunopathogenesis in patients with chronic HBV infection.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2014Article
- Thymic medullary epithelium and thymocyte self-tolerance require cooperation between CD28-CD80/86 and CD40-CD40L costimulatory pathways.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Article
- Targeting NKT cells and PD-L1 pathway results in augmented anti-tumor responses in a melanoma model.Cancer immunology, immunotherapy : CII · 2011Article
- Alternative memory in the CD8 T cell lineage.Trends in immunology · 2011Review
- NKT cell costimulation: experimental progress and therapeutic promise.Trends in molecular medicine · 2011Review
- Innate-like control of human iNKT cell autoreactivity via the hypervariable CDR3beta loop.PLoS biology · 2010Article
- Raising the NKT cell family.Nature immunology · 2010Review
- How do natural killer T cells help B cells?Expert review of vaccines · 2009Review
- Immunologic glycosphingolipidomics and NKT cell development in mouse thymus.Journal of proteome research · 2009Article
- The Wiskott-Aldrich syndrome protein is required for iNKT cell maturation and function.The Journal of experimental medicine · 2009Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
It has been demonstrated that the development of NKT cells requires CD1d. The contribution of costimulatory molecules in this process has not been studied. Here we show that in mice with targeted mutations of B7-1/2 and CD28, the TCRbeta(+)alpha-Galcer/CD1d(+) (iValpha14 NKT) subset is significantly reduced in the thymus, spleen and liver. This is mainly due to decreased cell proliferation; although increased cell death in the thymi of CD28-deficient mice was also observed. Moreover, in the B7-1/2- and CD28-deficient mice, we found a decreased percentage of the CD4(-)NK1.1(+) subset and a correspondingly increased portion of the CD4(+)NK1.1(-) subset. In addition, the mice with a targeted mutation of either B7 or CD28 had a reduced susceptibility to Con A induced hepatitis, which is known to be mediated by NKT cells. Our results demonstrate that the development, maturation and function of NKT cell are modulated by the costimulatory pathway and thus expand the horizon of costimulation into NKT, which is widely viewed as a bridge between innate and adaptive immunity. As such, costimulation may modulate all major branches of cell-mediated immunity, including T cells, NK cells and NKT cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.