ArticlePloS one2008
Role of Sox-9, ER81 and VE-cadherin in retinoic acid-mediated trans-differentiation of breast cancer cells.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- SOX9: an important factor in regulating breast cancer.European journal of medical research · 2025Review
- Cellular and micro-environmental responses influencing the antitumor activity of all-trans retinoic acid in breast cancer.Cell communication and signaling : CCS · 2024Review
- SOX9: The master regulator of cell fate in breast cancer.Biochemical pharmacology · 2020Review
- Vascular Transdifferentiation in the CNS: A Focus on Neural and Glioblastoma Stem-Like Cells.Stem cells international · 2016Review
- PGE2 signaling and its biosynthesis-related enzymes in cholangiocarcinoma progression.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Combined overexpression of HIVEP3 and SOX9 predicts unfavorable biochemical recurrence-free survival in patients with prostate cancer.OncoTargets and therapy · 2014Article
- Co-evolution of breast-to-brain metastasis and neural progenitor cells.Clinical & experimental metastasis · 2013Article
- Article
- Epigenetic regulation of cancer stem cells in liver cancer: current concepts and clinical implications.Journal of hepatology · 2010Review
- Article
- Oral administration of the anti-proliferative substance taurolidine has no impact on dextran sulfate sodium induced colitis-associated carcinogenesis in mice.Journal of carcinogenesis · 2010Article
- Article
- Identification of known and novel pancreas genes expressed downstream of Nkx2.2 during development.BMC developmental biology · 2009Article
- Cancer stem cells and hepatocellular carcinoma.Cancer biology & therapy · 2009Review
- Liver stem cells and hepatocellular carcinoma.Hepatology (Baltimore, Md.) · 2009Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Many aspects of development, tumor growth and metastasis depend upon the provision of an adequate vasculature. This can be a result of regulated angiogenesis, recruitment of circulating endothelial progenitors and/or vascular trans-differentiation. The present study demonstrates that treatment of SKBR-3 breast cancer cells with retinoic acid (RA), an important regulator of embryogenesis, cancer and other diseases, stimulates the formation of networks in Matrigel. RA-treatment of SKBR-3 cells co-cultured with human umbilical vein endothelial cells resulted in the formation of mixed structures. RA induces expression of many endothelial genes including vascular endothelial (VE) cadherin. VE-cadherin was also induced by RA in a number of other breast cancer cells. We show that RA-induced VE-cadherin is responsible for the RA-induced morphological changes. RA rapidly induced the expression of Sox-9 and ER81, which in turn form a complex on the VE-cadherin promoter and are required to mediate the transcriptional regulation of VE-cadherin by RA. These data indicate that RA may promote the expression of endothelial genes resulting in endothelial-like differentiation, or provide a mechanism whereby circulating endothelial progenitor cells could be incorporated into a growing organ or tumor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.