ArticleComparative and functional genomics2002
Overlapping antisense transcription in the human genome.
Article in Comparative and functional genomics, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 42 citations in OpenAlex.
- Natural antisense transcripts as versatile regulators of gene expression.Nature reviews. Genetics · 2024Review
- Parental bias in expression and interaction of genes in the equine placenta.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- lncRNA PCBP1-AS1 Aggravates the Progression of Hepatocellular Carcinoma via Regulating PCBP1/PRL-3/AKT Pathway.Cancer management and research · 2020Article
- Article
- An automated proteogenomic method uses mass spectrometry to reveal novel genes in Zea mays.Molecular & cellular proteomics : MCP · 2014Article
- Guided by RNAs: X-inactivation as a model for lncRNA function.Journal of molecular biology · 2013Review
- Natural antisense transcripts in plants: a review and identification in soybean infected with Phakopsora pachyrhizi SuperSAGE library.TheScientificWorldJournal · 2013Review
- Induction and activation of antiviral enzyme 2',5'-oligoadenylate synthetase by in vitro transcribed insulin mRNA and other cellular RNAs.Molecular biology reports · 2012Article
- Programmed fluctuations in sense/antisense transcript ratios drive sexual differentiation in S. pombe.Molecular systems biology · 2011Article
- RNAi screen indicates widespread biological function for human natural antisense transcripts.PloS one · 2010Article
- Regulation of fibroblast growth factor-2 by an endogenous antisense RNA and by argonaute-2.Molecular endocrinology (Baltimore, Md.) · 2010Article
- Genomic landscape of developing male germ cells.Birth defects research. Part C, Embryo today : reviews · 2009Review
- The antisense transcriptomes of human cells.Science (New York, N.Y.) · 2008Article
- Comparative expression profiling in grape (Vitis vinifera) berries derived from frequency analysis of ESTs and MPSS signatures.BMC plant biology · 2008Article
- Antisense transcription in the human cytomegalovirus transcriptome.Journal of virology · 2007Article
- Sense-antisense pairs in mammals: functional and evolutionary considerations.Genome biology · 2007Article
- Genome-wide in silico identification and analysis of cis natural antisense transcripts (cis-NATs) in ten species.Nucleic acids research · 2006Article
- Natural antisense transcripts with coding capacity in Arabidopsis may have a regulatory role that is not linked to double-stranded RNA degradation.Genome biology · 2005Article
- Mining SAGE data allows large-scale, sensitive screening of antisense transcript expression.Nucleic acids research · 2004Article
- Effects of length and location on the cellular response to double-stranded RNA.Microbiology and molecular biology reviews : MMBR · 2004Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Accumulating evidence indicates an important role for non-coding RNA molecules in eukaryotic cell regulation. A small number of coding and non-coding overlapping antisense transcripts (OATs) in eukaryotes have been reported, some of which regulate expression of the corresponding sense transcript. The prevalence of this phenomenon is unknown, but there may be an enrichment of such transcripts at imprinted gene loci. Taking a bioinformatics approach, we systematically searched a human mRNA database (RefSeq) for complementary regions that might facilitate pairing with other transcripts. We report 56 pairs of overlapping transcripts, in which each member of the pair is transcribed from the same locus. This allows us to make an estimate of 1000 for the minimum number of such transcript pairs in the entire human genome. This is a surprisingly large number of overlapping gene pairs and, clearly, some of the overlaps may not be functionally significant. Nonetheless, this may indicate an important general role for overlapping antisense control in gene regulation. EST databases were also investigated in order to address the prevalence of cases of imprinted genes with associated non-coding overlapping, antisense transcripts. However, EST databases were found to be completely inappropriate for this purpose.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.