ArticlePloS one2008
Genomic instability is associated with natural life span variation in Saccharomyces cerevisiae.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
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- Identification of genomic regions associated with early plant vigour in lentil (Journal of genetics · 2020Article
- Article
- Article
- Replicative and chronological aging in Saccharomyces cerevisiae.Cell metabolism · 2012Review
- Compromised cellular responses to DNA damage accelerate chronological aging by incurring cell wall fragility in Saccharomyces cerevisiae.Molecular biology reports · 2012Article
- Retrotransposition is associated with genome instability during chronological aging.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Conserved role of medium acidification in chronological senescence of yeast and mammalian cells.Aging · 2011Article
- A network-based approach on elucidating the multi-faceted nature of chronological aging in S. cerevisiae.PloS one · 2011Article
- Lessons on longevity from budding yeast.Nature · 2010Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Increasing genomic instability is associated with aging in eukaryotes, but the connection between genomic instability and natural variation in life span is unknown. We have quantified chronological life span and loss-of-heterozygosity (LOH) in 11 natural isolates of Saccharomyces cerevisiae. We show that genomic instability increases and mitotic asymmetry breaks down during chronological aging. The age-dependent increase of genomic instability generally lags behind the drop of viability and this delay accounts for approximately 50% of the observed natural variation of replicative life span in these yeast isolates. We conclude that the abilities of yeast strains to tolerate genomic instability co-vary with their replicative life spans. To the best of our knowledge, this is the first quantitative evidence that demonstrates a link between genomic instability and natural variation in life span.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.