ReviewNeuro-oncology2009
Health-related quality of life in patients with high-grade glioma.
Review in Neuro-oncology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01464177 (Prospective Randomized Phase II Trial of Hypofractionated Stereotactic Radiotherapy in Recurrent Glioblastoma Multiforme), which is not on this map. Cited by 40 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prospective Randomized Phase II Trial of Hypofractionated Stereotactic Radiotherapy in Recurrent Glioblastoma Multiforme
Who cites it
40 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Patient-reported outcomes as prognostic indicators for overall survival and progression-free survival in brain tumor patients - a systematic review and meta-analysis of randomized clinical trials.Journal of neuro-oncology · 2026Pooled it
- Quality-adjusted life years in glioma patients: a systematic review on currently available data and the lack of evidence-based utilities.Journal of neuro-oncology · 2019Pooled it
- Controlled rehabilitative and supportive care intervention trials in patients with high-grade gliomas and their caregivers: a systematic review.BMJ supportive & palliative care · 2016Pooled it
- Radiotherapy plus concurrent or sequential temozolomide for glioblastoma in the elderly: a meta-analysis.PloS one · 2013Pooled it
- Health-related quality of life, cognitive screening, and functional status in a randomized phase III trial (EF-14) of tumor treating fields with temozolomide compared to temozolomide alone in newly diagnosed glioblastoma.Journal of neuro-oncology · 2017Trial
- Trial
- The Dual Impact of Glioma Resection on Survival and Health-Related Quality of Life: Resect More, Live Better.Brain tumor research and treatment · 2026Article
- Comparison of Quality of Life in Postoperative High-Grade Glioma Patients Treated Using EORTC and RTOG Target Delineation Techniques for Postoperative Radiotherapy.Asian journal of neurosurgery · 2025Article
- Postsurgical motor function and processing speed as predictors of quality of life in patients with chronic-phase glioblastoma.Acta neurochirurgica · 2024Article
- Understanding experiences of cognitive decline and cognitive assessment from the perspectives of people with glioma and their caregivers: A qualitative interview study.International journal of nursing studies advances · 2024Article
- Unraveling the intricacies of glioblastoma progression and recurrence: insights into the role of NFYB and oxidative phosphorylation at the single-cell level.Frontiers in immunology · 2024Article
- Feasibility of intraoperative neuromonitoring and cortical/subcortical mapping in patients with cerebral lesions of highly functional localizations-pathway to case adapted monitoring and mapping procedures.Frontiers in oncology · 2023Article
- Examining the function of macrophage oxidative stress response and immune system in glioblastoma multiforme through analysis of single-cell transcriptomics.Frontiers in immunology · 2023Article
- The application of decision tree model based on clinicopathological risk factors and pre-operative MRI radiomics for predicting short-term recurrence of glioblastoma after total resection: a retrospective cohort study.American journal of cancer research · 2023Article
- Depression and Quality of Life in Patients with Gliomas: A Narrative Review.Journal of clinical medicine · 2022Review
- Assessing mobility in primary brain tumor patients: A descriptive feasibility study using two established mobility tests.Neuro-oncology practice · 2022Article
- Psychometric validity and reliability of the Danish version of the MD Anderson Symptom Inventory Brain Tumor Module.Neuro-oncology practice · 2021Article
- Article
- Quality improvement of neuro-oncology services: integrating the routine collection of patient-reported, health-related quality-of-life measures.Neuro-oncology practice · 2019Article
- [EJNMMI research · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Health-related quality of life (HRQOL) has become an increasingly important endpoint in cancer studies; however, the research into the HRQOL of patients with high-grade glioma (HGG) is sparse compared with that for patients with other neoplasms. Owing to the specific location and poor prognosis, it is more important and difficult to study HRQOL in patients with HGG than in those with other tumors; furthermore, the study of HRQOL in patients with HGG differs from that for patients with other tumors. In this review, we identified and compared the most frequently used instruments to assess HRQOL; analyzed specific facets and determinants of HRQOL (such as sex, tumor location and histological classification, depression, and cognitive function), as well as the association between HRQOL and survival; and appraised the effects of new treatments on HRQOL in patients with HGG from randomized controlled trials. Furthermore, we detected broadly existing problems and many contradictory outcomes and gave some proper interpretation and suggestions regarding them.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.