ArticleThe American journal of psychiatry2008
A genome screen for quantitative trait loci influencing schizophrenia and neurocognitive phenotypes.
Article in The American journal of psychiatry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
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46 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
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- Exome Sequence Data From Multigenerational Families Implicate AMPA Receptor Trafficking in Neurocognitive Impairment and Schizophrenia Risk.Schizophrenia bulletin · 2016Article
- GWAS for executive function and processing speed suggests involvement of the CADM2 gene.Molecular psychiatry · 2016Article
- Multimodal Brain and Behavior Indices of Psychosis Risk.Nebraska Symposium on Motivation. Nebraska Symposium on Motivation · 2016Review
- From Linkage Studies to Epigenetics: What We Know and What We Need to Know in the Neurobiology of Schizophrenia.Frontiers in neuroscience · 2016Review
- Development of an abbreviated form of the Penn Line Orientation Test using large samples and computerized adaptive test simulation.Psychological assessment · 2015Article
- Common genetic variation and schizophrenia polygenic risk influence neurocognitive performance in young adulthood.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2015Article
- Association between 5q23.2-located polymorphism of CTXN3 gene (Cortexin 3) and schizophrenia in European-Caucasian males; implications for the aetiology of schizophrenia.Behavioral and brain functions : BBF · 2015Article
- Psychometric properties of the Penn Computerized Neurocognitive Battery.Neuropsychology · 2015Article
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11 authors at 1 institution in 1 country.
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Abstract
objectiveDeficits in neurocognitive function have been demonstrated in individuals with schizophrenia and in the unaffected family members of these individuals. Genetic studies of such complementary traits, along with traditional analyses of diagnosis, may help to elucidate the biological pathways underlying familial liability to schizophrenia and related disorders. The authors conducted a multiplex, multigenerational family study using a genome-wide screen for schizophrenia and related neurocognitive phenotypes.
methodParticipants were 1) 676 European American individuals from 43 families, ascertained through an individual with schizophrenia, and 2) 236 healthy comparison subjects. Participants were evaluated clinically and examined through the use of a computerized neurocognitive test battery that provided measures of accuracy and speed on the cognitive domains of abstraction and mental flexibility; attention; verbal, face, and spatial memory; language and reasoning; spatial and emotion processing; and sensorimotor dexterity. A genome-wide linkage screen was also performed. Healthy comparison subjects were included in order to obtain normative phenotypic data but were not genotyped.
resultsSignificant evidence for linkage of schizophrenia to chromosome 19q was observed. Analysis of cognitive traits revealed significant linkage to chromosome 5q for the domains of abstraction and mental flexibility. A variety of other neurocognitive traits also showed nominal evidence of linkage to the 5q region. Joint analyses with diagnosis suggested that this quantitative trait locus may also influence schizophrenia.
conclusionsAlthough chromosome 5 has been implicated in previous linkage studies of schizophrenia, the identification of the chromosome 19 quantitative trait locus is a novel finding. The identification of the chromosome 5 quantitative trait locus through linkage to neurocognitive phenotypes in the present study may inform functional hypotheses pertaining to how genotypes are connected to disease.
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