Evidence map›Paper›PMID 18627673›Full record

ReviewCurrent psychiatry reports2008

Schizophrenia: from genes to phenes to disease.

Charlotte L Allan, Alastair G Cardno, Peter McGuffin

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current psychiatry reports, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. TSNARE1 polymorphisms are associated with schizophrenia susceptibility in Han Chinese.Journal of neural transmission (Vienna, Austria : 1996) · 2015
    Article
  3. Article
  4. Article
  5. Genetics of schizophrenia from a clinicial perspective.International review of psychiatry (Abingdon, England) · 2012
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Charlotte L AllanAcademic Unit of Psychiatry and Behavioral Sciences, Leeds Institute of Health Sciences, University of Leeds, Charles Thackrah Building, 101 Clarendon Road, Leeds LS2 9LJ, United Kingdom. charlotteallan@nhs.net
Alastair G Cardno
Peter McGuffin

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This article provides an overview of the past year's literature on schizophrenia genetics. Quantitative genetics continues to be an important foundation in which family and twin studies have been used to evaluate potential endophenotypes. Research in molecular genetics has focused on detecting multiple genes of small effect, and developments relating to key positional and functional candidate genes are reviewed. Large-scale, multicenter studies are proving to be important in this quest. Research using neuroimaging and animal modeling studies continues to link genotype with phenotype. It is increasingly apparent that some candidate genes considered important in schizophrenia are likely to be relevant to the etiology of other psychotic disorders, including bipolar disorder. This notion may challenge traditional disease classifications, not only in research but potentially in clinical practice.

Indexed as

GenotypePhenotypeCatechol O-MethyltransferaseChromosome AberrationsDopamineGene ExpressionGenetic LinkageHumansMethylenetetrahydrofolate Reductase (NADPH2)Nerve Tissue ProteinsSchizophreniaTwinsCatechol O-MethyltransferaseDISC1 protein, humanDopamineMethylenetetrahydrofolate Reductase (NADPH2)Nerve Tissue Proteins

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.