ReviewEpilepsia2008
Human herpes virus 6B: a possible role in epilepsy?
Review in Epilepsia, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 121 citations in OpenAlex.
- Febrile status epilepticus and epileptogenesis: The FEBSTAT study.Epilepsia open · 2025Article
- The Development of Epilepsy Following CNS Viral Infections: Mechanisms.Current neurology and neuroscience reports · 2024Review
- Trigeminal Neuralgia Secondary to Herpes Simplex Virus Type 1 Infection Treated With Oral Acyclovir.Cureus · 2024Article
- A Rare Case of HHV-6 Encephalitis in an Immunocompetent Host: Case Report and Literature Review.Cureus · 2022Article
- Family Herpesviridae and neuroinfections: current status and research in progress.Memorias do Instituto Oswaldo Cruz · 2022Review
- Human herpes virus type-6 is associated with central nervous system infections in children in Sudan.African journal of laboratory medicine · 2022Article
- Suspected Post-ictal Psychosis in Temporal Lobe Epilepsy Secondary to Human Herpesvirus 6 Encephalitis.Cureus · 2021Article
- Human Herpesviruses 6A and 6B in Brain Diseases: Association versus Causation.Clinical microbiology reviews · 2020Review
- Central Nervous System Infection-Related Isolated Hippocampal Atrophy as Another Subtype of Medial Temporal Lobe Epilepsy with Hippocampal Atrophy: A Comparison to Conventional Medial Temporal Lobe Epilepsy with Hippocampal Atrophy.Journal of clinical neurology (Seoul, Korea) · 2020Article
- HHV-6 and hippocampal volume in patients with mesial temporal sclerosis.Annals of clinical and translational neurology · 2020Article
- Persistent Roseoloviruses Infection in Adult Patients with Epilepsy.Brain sciences · 2020Article
- Inherited Chromosomally Integrated Human Herpesvirus 6 Demonstrates Tissue-Specific RNA ExpressionJournal of virology · 2019Article
- Viral Triggers and Inflammatory Mechanisms in Pediatric Epilepsy.Molecular neurobiology · 2019Review
- Herpesvirus trigger accelerates neuroinflammation in a nonhuman primate model of multiple sclerosis.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Interactions Between Epilepsy and Plasticity.Pharmaceuticals (Basel, Switzerland) · 2018Review
- Detection frequency of human herpesviruses-6A, -6B, and -7 genomic sequences in central nervous system DNA samples from post-mortem individuals with unspecified encephalopathy.Journal of neurovirology · 2016Article
- Article
- Type specific Real time PCR for detection of human herpes virus 6 in schizophrenia and bipolar patients: a case control study.BMC psychiatry · 2015Article
- Laboratory and clinical aspects of human herpesvirus 6 infections.Clinical microbiology reviews · 2015Review
- Modulatory effects on dendritic cells by human herpesvirus 6.Frontiers in microbiology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Human herpes virus 6 (HHV6) infection is nearly ubiquitous in childhood and may include central nervous system invasion. There are two variants, HHV6A and HHV6B. Usually asymptomatic, it is associated with the common, self-limited childhood illness roseola infantum and rarely with more severe syndromes. In patients with immune compromise, subsequent reactivation of viral activity may lead to severe limbic encephalitis. HHV6 has been identified as a possible etiologic agent in multiple sclerosis, myocarditis, and encephalitis. A preponderance of evidence supports an association between HHV6 and febrile seizures. An ongoing multicenter study is investigating possible links between HHV6 infection, febrile status epilepticus, and development of mesial temporal sclerosis (MTS). Investigation of temporal lobectomy specimens showed evidence of active HHV6B but not HHV6A replication in hippocampal astrocytes in about two-thirds of patients with MTS but not other causes of epilepsy. It has been suggested that HHV6B may cause "excitotoxicity" by interfering with astrocyte excitatory amino acid transport. Although conventional inflammatory changes are not found in most MTS specimens, inflammatory modulators may play a role in neuronal injury leading to MTS as well. If the link between early viral infection, complex or prolonged febrile seizures, and later development of intractable temporal lobe epilepsy is confirmed, new therapeutic approaches to a common intractable epilepsy syndrome may be possible.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.