ArticleBiological chemistry2008
Epigallocatechin gallate inhibits endothelial exocytosis.
Article in Biological chemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 40 citations in OpenAlex.
- Consumption of Coffee and Tea Is Associated with Macular Retinal Nerve Fiber Layer Thickness: Results from the UK Biobank.Nutrients · 2023Article
- Potential of Polyamide Nanofibers With Natamycin, Rosemary Extract, and Green Tea Extract in Active Food Packaging Development: Interactions With Food Pathogens and Assessment of Microbial Risks Elimination.Frontiers in microbiology · 2022Article
- Nanotechnological approach to delivering nutraceuticals as promising drug candidates for the treatment of atherosclerosis.Drug delivery · 2021Review
- Nutraceuticals as therapeutic agents for atherosclerosis.Biochimica et biophysica acta. Molecular basis of disease · 2018Review
- Nutraceutical therapies for atherosclerosis.Nature reviews. Cardiology · 2016Review
- Plant-derived immunomodulators: an insight on their preclinical evaluation and clinical trials.Frontiers in plant science · 2015Review
- The antimicrobial possibilities of green tea.Frontiers in microbiology · 2014Review
- Geniposide inhibits high glucose-induced cell adhesion through the NF-kappaB signaling pathway in human umbilical vein endothelial cells.Acta pharmacologica Sinica · 2010Article
- Increased endothelial exocytosis and generation of endothelin-1 contributes to constriction of aged arteries.Circulation research · 2010Article
- Flavanols and anthocyanins in cardiovascular health: a review of current evidence.International journal of molecular sciences · 2010Review
- Polyphenols and aging.Current aging science · 2010Review
- Genipin inhibits endothelial exocytosis via nitric oxide in cultured human umbilical vein endothelial cells.Acta pharmacologica Sinica · 2009Article
- Tea polyphenols regulate key mediators on inflammatory cardiovascular diseases.Mediators of inflammation · 2009Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Consumption of green tea is associated with a decrease in cardiovascular mortality. The beneficial health effects of green tea are attributed in part to polyphenols, organic compounds found in tea that lower blood pressure, reduce body fat, decrease LDL cholesterol, and inhibit inflammation. We hypothesized that epigallocatechin gallate (EGCG), the most abundant polyphenol in tea, inhibits endothelial exocytosis, the initial step in leukocyte trafficking and vascular inflammation. To test this hypothesis, we treated human umbilical-vein endothelial cells with EGCG and other polyphenols, and then measured endothelial exocytosis. We found that EGCG decreases endothelial exocytosis in a concentration-dependent manner, with the effects most prominent after 4 h of treatment. Other catechin polyphenols had no effect on endothelial cells. By inhibiting endothelial exocytosis, EGCG decreases leukocyte adherence to endothelial cells. In searching for the mechanism by which EGCG affects endothelial cells, we found that EGCG increases Akt phosphorylation, eNOS phosphorylation, and nitric oxide (NO) production. NOS inhibition revealed that NO mediates the anti-inflammatory effects of EGCG. Our data suggest that polyphenols can decrease vascular inflammation by increasing the synthesis of NO, which blocks endothelial exocytosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.