ArticleBiomacromolecules2008
New design of helix bundle peptide-polymer conjugates.
Article in Biomacromolecules, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Amino Acid Sequence Controls Enhanced Electron Transport in Heme-Binding Peptide Monolayers.ACS central science · 2025Article
- Genetically Fused Resilin-like Polypeptide-Coiled Coil Bundlemer Conjugates Exhibit Tunable Multistimuli-Responsiveness and Undergo Nanofibrillar Assembly.Biomacromolecules · 2024Article
- Impact of the PEG length and PEGylation site on the structural, thermodynamic, thermal, and proteolytic stability of mono-PEGylated alpha-1 antitrypsin.Protein science : a publication of the Protein Society · 2022Article
- Biomaterials via peptide assembly: Design, characterization, and application in tissue engineering.Acta biomaterialia · 2022Review
- Tunable Protein Hydrogels: Present State and Emerging Development.Advances in biochemical engineering/biotechnology · 2021Article
- Molecular Simulations of PEGylated Biomolecules, Liposomes, and Nanoparticles for Drug Delivery Applications.Pharmaceutics · 2020Review
- New Developments in Medical Applications of Hybrid Hydrogels Containing Natural Polymers.Molecules (Basel, Switzerland) · 2020Review
- Understanding Peptide Oligomeric State in Langmuir Monolayers of Amphiphilic 3-Helix Bundle-Forming Peptide-PEG Conjugates.Biomacromolecules · 2016Article
- How PEGylation influences protein conformational stability.Current opinion in chemical biology · 2016Review
- Synthesis and Self-Assembly of Bundle-Forming α-Helical Peptide-Dendron Hybrids.Biomacromolecules · 2016Article
- How special is the biochemical function of native proteins?F1000Research · 2016Review
- Self-assembled 20-nm (64)Cu-micelles enhance accumulation in rat glioblastoma.Journal of controlled release : official journal of the Controlled Release Society · 2015Article
- Implications of the small number of distinct ligand binding pockets in proteins for drug discovery, evolution and biochemical function.Bioorganic & medicinal chemistry letters · 2015Review
- Thermoresponsive self-assembly of nanostructures from a collagen-like peptide-containing diblock copolymer.Macromolecular bioscience · 2015Article
- Effect of alkyl length of peptide-polymer amphiphile on cargo encapsulation stability and pharmacokinetics of 3-helix micelles.Biomacromolecules · 2014Article
- Hierarchical cascades of instability govern the mechanics of coiled coils: helix unfolding precedes coil unzipping.Biophysical journal · 2014Article
- Evaluation of doxorubicin-loaded 3-helix micelles as nanocarriers.Biomacromolecules · 2013Article
- Collagen-like peptides and peptide-polymer conjugates in the design of assembled materials.European polymer journal · 2013Article
- 3-Helix micelles stabilized by polymer springs.Journal of the American Chemical Society · 2012Article
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Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
We present a new design of peptide-polymer conjugates where a polymer chain is covalently linked to the side chain of a helix bundle-forming peptide. The effect of conjugated polymer chains on the peptide structure was examined using a de novo designed three-helix bundle and a photoactive four-helix bundle. Upon attachment of poly(ethylene glycol) to the exterior of the coiled-coil helix bundle, the peptide secondary structure was stabilized and the tertiary structure, that is, the coiled-coil helix bundle, was retained. When a heme-binding peptide as an example is used, the new peptide-polymer conjugate architecture also preserves the built-in functionalities within the interior of the helix bundle. It is expected that the conjugated polymer chains act to mediate the interactions between the helix bundle and its external environment. Thus, this new peptide-polymer conjugate design strategy may open new avenues to macroscopically assemble the helix bundles and may enable them to function in nonbiological environments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.