ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2008
Cardiac expression of the Drosophila Transglutaminase (CG7356) gene is directly controlled by myocyte enhancer factor-2.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Single-cell profiling of the developing embryonic heart in Drosophila.Development (Cambridge, England) · 2023Article
- Transglutaminase 3 negatively regulates immune responses on the heart of the mosquito, Anopheles gambiae.Scientific reports · 2022Article
- Food supplementation with wheat gluten leads to climbing performance decline inmicroPublication biology · 2022Article
- Transglutaminase inhibition stimulates hematopoiesis and reduces aggressive behavior of crayfish,The Journal of biological chemistry · 2019Article
- On the Morphology of the Drosophila Heart.Journal of cardiovascular development and disease · 2016Review
- Regulatory Networks that Direct the Development of Specialized Cell Types in theJournal of cardiovascular development and disease · 2016Article
- Over-expression of transglutaminase in the Drosophila eye imaginal disc induces a rough eye phenotype.Molecular and cellular biochemistry · 2010Article
- Inhibition of transglutaminase 2 mitigates transcriptional dysregulation in models of Huntington disease.EMBO molecular medicine · 2010Article
- Serotonergic dystrophy induced by excess serotonin.Molecular and cellular neurosciences · 2010Article
- Cardiac gene regulatory networks in Drosophila.Biochimica et biophysica acta · 2009Review
- Cardiac remodeling in Drosophila arises from changes in actin gene expression and from a contribution of lymph gland-like cells to the heart musculature.Mechanisms of developmentArticle
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The myocyte enhancer factor-2 (MEF2) family of transcription factors plays key roles in the activation of muscle structural genes. In Drosophila, MEF2 accumulates at high levels in the embryonic muscles, where it activates target genes throughout the mesoderm. Here, we identify the Transglutaminase gene (Tg; CG7356) as a direct transcriptional target of MEF2 in the cardiac musculature. Tg is expressed in cells forming the inflow tracts of the dorsal vessel, and we identify the enhancer responsible for this expression. The enhancer contains three binding sites for MEF2, and can be activated by MEF2 in tissue culture and in vivo. Moreover, loss of MEF2 function, or removal of the MEF2 binding sites from the enhancer, results in loss of Tg expression. These studies identify a new MEF2 target in the cardiac musculature. These studies provide a possible mechanism for the activation of transglutaminase genes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.