ReviewClinical reviews in allergy & immunology2009
Atypical p-ANCA in PSC and AIH: a hint toward a "leaky gut"?
Review in Clinical reviews in allergy & immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 81 citations in OpenAlex.
- Gut microbiota of liver transplantation recipients.Scientific reports · 2017Trial
- Microbial cues and T cell immunity: deciphering their interactions in chronic liver disease.Experimental & molecular medicine · 2026Review
- Mapping organ-associated autoantigenic landscapes in systemic lupus erythematosus.Frontiers in immunology · 2026Review
- Autoantibodies to beta tubulin in autoimmune liver diseases-Relation to pANCA and clinical relevance.Clinical and experimental immunology · 2024Article
- The Relationships between Intestinal Permeability and Target Antibodies for a Spectrum of Autoimmune Diseases.International journal of molecular sciences · 2023Article
- The link betweenAnnals of hepato-biliary-pancreatic surgery · 2023Review
- Serological biomarkers for management of primary sclerosing cholangitis.World journal of gastroenterology · 2022Review
- HLA, gut microbiome and hepatic autoimmunity.Frontiers in immunology · 2022Review
- Case Report: Simultaneously Developed Amyopathic Dermatomyositis and Autoimmune Sclerosing Cholangitis - a Coincidence or a Shared Immunopathogenesis?Frontiers in immunology · 2022Article
- Looking into key bacterial proteins involved in gut dysbiosis.World journal of methodology · 2021Review
- Lactitol Supplementation Modulates Intestinal Microbiome in Liver Cirrhotic Patients.Frontiers in medicine · 2021Article
- CTLA-4 Expression Plays a Role in PSC and PBC Progression.Diseases (Basel, Switzerland) · 2020Article
- Sulphite oxidase (SO) - a mitochondrial autoantigen as target for humoral and cellular immune reactions in primary sclerosing cholangitis.BMC gastroenterology · 2018Article
- Autoantibodies in Autoimmune Liver Disease-Clinical and Diagnostic Relevance.Frontiers in immunology · 2018Review
- Diagnosis and Management of Autoimmune Hepatitis: Current Status and Future Directions.Gut and liver · 2016Review
- Gut Inflammation in Primary Sclerosing Cholangitis and Autoimmune Sclerosing Cholangitis-Contrasting Pattern of Liver-gut Cross Talk.EBioMedicine · 2015Article
- Hepatobiliary manifestations of ulcerative colitis: an example of gut-liver crosstalk.Gastroenterology report · 2014Review
- A Review of the Challenges Associated with the Diagnosis and Therapy of Primary Sclerosing Cholangitis.Journal of clinical and translational hepatology · 2014Review
- Pathogenesis of primary sclerosing cholangitis and advances in diagnosis and management.Gastroenterology · 2013Review
- Autoantibodies in liver disease: important clues for the diagnosis, disease activity and prognosis.Auto- immunity highlights · 2013Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Primary sclerosing cholangitis (PSC) and autoimmune hepatitis (AIH) are enigmatic chronic inflammatory diseases of the liver, which are frequently associated with chronic inflammatory bowel diseases. Both types of liver disease share various distinct autoantibodies such as atypical perinuclear antineutrophil cytoplasmic antibodies (p-ANCA), and thus are considered autoimmune disorders with atypical features. The discovery that atypical p-ANCA recognize both tubulin beta isoform 5 in human neutrophils and the bacterial cell division protein FtsZ has renewed the discussion on the potential role of microorganisms in the pathogenesis of both diseases. In this paper, we review the evidence for microbial infection in PSC and AIH and discuss new concepts how cross-recognition between microbial antigens in the gut and host components by the immune system along with stimulation of pattern recognition receptors might give rise to chronic hepatic inflammatory disorders with features of autoimmunity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.