ReviewPhotosynthesis research
Directing the evolution of Rubisco and Rubisco activase: first impressions of a new tool for photosynthesis research.
Review in Photosynthesis research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 89 citations in OpenAlex.
- Review
- Review
- Enzymatic Conversion of COChemical reviews · 2023Review
- Molecular mechanism of Rubisco activase: Dynamic assembly and Rubisco remodeling.Frontiers in molecular biosciences · 2023Review
- Combinatorial use of environmental stresses and genetic engineering to increase ethanol titres in cyanobacteria.Biotechnology for biofuels · 2021Review
- Enhancing crop yield by using Rubisco activase to improve photosynthesis under elevated temperatures.Stress biology · 2021Review
- Functional reconstitution of a bacterial COeLife · 2020Article
- Recent Advances in Developing Artificial Autotrophic Microorganism for Reinforcing COFrontiers in microbiology · 2020Review
- Directed Evolution of an Improved Rubisco; In Vitro Analyses to Decipher Fact from Fiction.International journal of molecular sciences · 2019Article
- Selection of Cyanobacterial (mBio · 2019Article
- Directed -in vitro- evolution of Precambrian and extant Rubiscos.Scientific reports · 2018Article
- An improvedThe Journal of biological chemistry · 2018Article
- Photosynthetic Properties and Potentials for Improvement of Photosynthesis in Pale Green Leaf Rice under High Light Conditions.Frontiers in plant science · 2017Article
- The Diverse AAA+ Machines that Repair Inhibited Rubisco Active Sites.Frontiers in molecular biosciences · 2017Review
- RubisCO selection using the vigorously aerobic and metabolically versatile bacterium Ralstonia eutropha.The FEBS journal · 2016Article
- Towards engineering carboxysomes into C3 plants.The Plant journal : for cell and molecular biology · 2016Article
- Large variation in the Rubisco kinetics of diatoms reveals diversity among their carbon-concentrating mechanisms.Journal of experimental botany · 2016Article
- Evolving Methanococcoides burtonii archaeal Rubisco for improved photosynthesis and plant growth.Scientific reports · 2016Article
- Improving recombinant Rubisco biogenesis, plant photosynthesis and growth by coexpressing its ancillary RAF1 chaperone.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Biocatalysis for the application of CO2 as a chemical feedstock.Beilstein journal of organic chemistry · 2015Review
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During the last decade the practice of laboratory-directed protein evolution has become firmly established as a versatile tool in biochemical research by enabling molecular evolution toward desirable phenotypes or detection of novel structure-function interactions. Applications of this technique in the field of photosynthesis research are still in their infancy, but recently first steps have been reported in the directed evolution of the CO(2)-fixing enzyme Rubisco and its helper protein Rubisco activase. Here we summarize directed protein evolution strategies and review the progressive advances that have been made to develop and apply suitable selection systems for screening mutant forms of these enzymes that improve the fitness of the host organism. The goal of increasing photosynthetic efficiency of plants by improving the kinetics of Rubisco has been a long-term goal scoring modest successes. We discuss how directed evolution methodologies may one day be able to circumvent the problems encountered during this venture.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.