SynthesisIntensive care medicine2008
Natriuretic peptides in acute pulmonary embolism: a systematic review.
Synthesis in Intensive care medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 127 citations in OpenAlex.
- Article
- Life expectancy in cancer patients with pulmonary thromboembolism: From clinical prognostic biomarkers and paraclinical investigations to therapeutic approaches (Review).Experimental and therapeutic medicine · 2024Review
- Decoding Pulmonary Embolism: Pathophysiology, Diagnosis, and Treatment.Biomedicines · 2024Review
- Article
- [Natriuretic peptides in intensive care medicine].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2023Review
- Interventional therapies for pulmonary embolism.Nature reviews. Cardiology · 2023Review
- Mechanical Circulatory Support and Critical Care Management of High-Risk Acute Pulmonary Embolism.Interventional cardiology clinics · 2023Review
- MR-proADM and MR-proANP levels in patients with acute pulmonary embolism.Journal of medical biochemistry · 2020Article
- Review
- Could HIF-1α be a novel biomarker for the clinical course and treatment of pulmonary embolism?Turkish journal of medical sciences · 2020Article
- Atrial and Brain Natriuretic Peptides- Benefits and Limits of their use in Cardiovascular Diseases.Current cardiology reviews · 2019Review
- [Pulmonary embolism mimicking acute coronary syndrome].The Pan African medical journal · 2019Article
- Rapid on-site evaluation of routine biochemical parameters to predict right ventricular dysfunction in and the prognosis of patients with acute pulmonary embolism upon admission to the emergency room.Journal of clinical laboratory analysis · 2018Article
- Evaluation of cardiac biomarkers and right ventricular dysfunction in patients with acute pulmonary embolism.Anatolian journal of cardiology · 2016Article
- MR-proANP, MR-proADM, and PCT in Patients Presenting with Acute Dyspnea in a Medical Emergency Unit.Lung · 2016Article
- Acute pulmonary embolism with electrocardiagraphic changes mimicking acute coronary syndrome: a case report and literature review.International journal of clinical and experimental medicine · 2015Article
- Emergent surgical pulmonary embolectomy in a pregnant woman: case report and literature review.Texas Heart Institute journal · 2014Review
- B-type natriuretic peptide as a predictor of outcome in a general intensive care unit.HSR proceedings in intensive care & cardiovascular anesthesia · 2011Article
- Utility of natriuretic peptide testing in the evaluation and management of acute decompensated heart failure.Heart failure reviews · 2010Review
- Clinical, historical and diagnostic findings associated with right ventricular dysfunction in patients with central and non-massive pulmonary embolism.Internal and emergency medicine · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPatients with pulmonary embolism (PE) have a high risk of death, and it is important to recognize factors associated with higher mortality. Recently, several biomarkers have been studied for risk stratification in patients with PE.
objectivesEvaluate the available evidence on (a) the accuracy of brain natriuretic peptide (BNP) and N-terminal pro-brain natriuretic peptide (NT-proBNP) for the diagnosis of right ventricular dysfunction and (b) their value as a prognostic factor of all-cause in-hospital or short-term mortality in patients with PE. DATA SOURCES: MEDLINE, Embase, and citation review of relevant primary and review articles. SELECTION CRITERIA: We selected studies evaluating the accuracy of BNP or NT-proBNP for the diagnosis of right ventricular dysfunction. We also selected studies that reported data on BNP or NT-proBNP as a predictor of short-term mortality in patients with PE.
resultsSixteen studies met our inclusion criteria. The pooled diagnostic odds ratio for the diagnosis of right ventricular dysfunction in pulmonary embolism was 39.45 (95% CI; 15.54-100.12) and 24.73 (95% CI 2.02-302.37) for BNP and NT-proBNP, respectively. The pooled odds ratio for all-cause in-hospital or short-term mortality was 6 (95% CI 1.31-27.43; p: 0.021) and 16.12 (95% CI 3.1-83.68; p: 0.001) for BNP (cutoff: 100 pg/ml) and NT-proBNP (cutoff: 600 ng/L), respectively.
conclusionThe results of this meta-analysis indicate that BNP and NT-proBNP are associated with the diagnosis of right ventricular dysfunction (RVD) in patients with an acute PE and are significant predictors of all-cause in-hospital or short-term mortality in these patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.