SynthesisMolecular psychiatry2010
Minor physical anomalies in autism: a meta-analysis.
Synthesis in Molecular psychiatry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 74 citations in OpenAlex.
- From spatial patterning to coordinated execution: a cross-system framework for autism spectrum disorder.Frontiers in psychiatry · 2026Review
- 25 years into research with the Méhes Scale, a comprehensive scale of modern dysmorphology.Frontiers in psychiatry · 2024Review
- Pre-autism: What a paediatrician should know about early diagnosis of autism.World journal of clinical pediatrics · 2023Review
- Observational
- Association between ultrasonography foetal anomalies and autism spectrum disorder.Brain : a journal of neurology · 2022Article
- Genome-wide rare variant score associates with morphological subtypes of autism spectrum disorder.Nature communications · 2022Article
- Increased prevalence of minor physical anomalies in patients with epilepsy.Scientific reports · 2022Article
- Correlational research on facial and clinical characteristics of adolescents with obsessive-compulsive disorder.BMC psychiatry · 2021Article
- Identification of Essential, Equivocal and Complex Autism by the Autism Dysmorphology Measure: An Observational Study.Journal of autism and developmental disorders · 2021Observational
- A Preliminary Study on Cranio-Facial Characteristics Associated with Minor Neurological Dysfunctions (MNDs) in Children with Autism Spectrum Disorders (ASD).Brain sciences · 2020Article
- Mapping the Relationship between Dysmorphology and Cognitive, Behavioral, and Developmental Outcomes in Children with Autism Spectrum Disorder.Autism research : official journal of the International Society for Autism Research · 2020Article
- Cranio-Facial Characteristics in Children with Autism Spectrum Disorders (ASD).Journal of clinical medicine · 2019Article
- Observational
- Syndromic autism spectrum disorders: moving from a clinically defined to a molecularly defined approach.Dialogues in clinical neuroscience · 2017Review
- Minor physical anomalies in neurodevelopmental disorders: a twin study.Child and adolescent psychiatry and mental health · 2017Article
- Article
- Environmental and state-level regulatory factors affect the incidence of autism and intellectual disability.PLoS computational biology · 2014Article
- Use of dysmorphology for subgroup classification on autism spectrum disorder in Chinese children.Journal of autism and developmental disorders · 2014Article
- A critical review of the research on the extreme male brain theory and digit ratio (2D:4D).Journal of autism and developmental disorders · 2013Review
- Predictive value of morphological features in patients with autism versus normal controls.Journal of autism and developmental disorders · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autism is a complex neurodevelopmental disorder in which the interactions of genetic, epigenetic and environmental influences play a causal role. Despite the compelling evidence for a strong heritability, the etiology and molecular mechanisms underlying autism remain unclear. High phenotypic variability and genetic heterogeneity confounds the identification of susceptibility genes. The lack of robust indicators to tackle this complexity in autism has led researchers to seek for novel diagnostic tools to create homogenous subgroups. Several studies have indicated that patients with autism have higher rates of minor physical anomalies (MPAs) and that MPAs may serve as a diagnostic tool; however, the results have been inconsistent. Using the cumulative data from seven studies on MPAs in autism, this meta-analysis seeks to examine whether the aggregate data provide evidence of a large mean effect size and statistical significance for MPAs in autism. It covers the studies using multiple research methods till June 2007. The current results from seven studies suggested a significant association of MPAs in autism with a robust pooled effect size (d=0.84), and thereby provide the strongest evidence to date about the close association between MPAs and autism. Our results emphasize the importance of MPAs in the identification of heterogeneity in autism and suggest that the success of future autism genetics research will be exploited by the use of MPAs. Implications for the design of future studies on MPAs in autism are discussed and suggestions for further investigation of these important markers are proposed. Clarifying this relation might improve understanding of risk factors and molecular mechanisms in autism.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.