ArticleLearning & memory (Cold Spring Harbor, N.Y.)2008
Medial auditory thalamus inactivation prevents acquisition and retention of eyeblink conditioning.
Article in Learning & memory (Cold Spring Harbor, N.Y.), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 34 citations in OpenAlex.
- Reevaluating the ability of cerebellum in associative motor learning.Scientific reports · 2019Article
- Medial Auditory Thalamus Is Necessary for Expression of Auditory Trace Eyelid Conditioning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Cerebellar Processing Common to Delay and Trace Eyelid Conditioning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Amygdala central nucleus modulation of cerebellar learning with a visual conditioned stimulus.Neurobiology of learning and memory · 2018Article
- A neural model of normal and abnormal learning and memory consolidation: adaptively timed conditioning, hippocampus, amnesia, neurotrophins, and consciousness.Cognitive, affective & behavioral neuroscience · 2017Article
- Article
- The role of working memory and declarative memory in trace conditioning.Neurobiology of learning and memory · 2016Review
- Amygdala Modulation of Cerebellar Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- The impact of hippocampal lesions on trace-eyeblink conditioning and forebrain-cerebellar interactions.Behavioral neuroscience · 2015Review
- Medial auditory thalamus is necessary for acquisition and retention of eyeblink conditioning to cochlear nucleus stimulation.Learning & memory (Cold Spring Harbor, N.Y.) · 2015Article
- Eyeblink Conditioning and Novel Object Recognition in the Rabbit: Behavioral Paradigms for Assaying Psychiatric Diseases.Frontiers in psychiatry · 2015Review
- Sensory system development influences the ontogeny of eyeblink conditioning.Developmental psychobiology · 2014Article
- Inactivation of the ventral lateral geniculate and nucleus of the optic tract impairs retention of visual eyeblink conditioning.Behavioral neuroscience · 2013Article
- Visual cortical contributions to associative cerebellar learning.Neurobiology of learning and memory · 2013Article
- Article
- Classical eyeblink conditioning using electrical stimulation of caudal mPFC as conditioned stimulus is dependent on cerebellar interpositus nucleus in guinea pigs.Acta pharmacologica Sinica · 2012Article
- Multiple sites of extinction for a single learned response.Journal of neurophysiology · 2012Article
- Conditioned fear in adult rats is facilitated by the prior acquisition of a classically conditioned motor response.Neurobiology of learning and memory · 2010Article
- Associative plasticity in the medial auditory thalamus and cerebellar interpositus nucleus during eyeblink conditioning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Medial auditory thalamic input to the lateral pontine nuclei is necessary for auditory eyeblink conditioning.Neurobiology of learning and memory · 2010Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The auditory conditioned stimulus (CS) pathway that is necessary for delay eyeblink conditioning was investigated using reversible inactivation of the medial auditory thalamic nuclei (MATN) consisting of the medial division of the medial geniculate (MGm), suprageniculate (SG), and posterior intralaminar nucleus (PIN). Rats were given saline or muscimol infusions into the MATN contralateral to the trained eye before each of four conditioning sessions with an auditory CS. Rats were then given four additional sessions without infusions to assess savings from the initial training. All rats were then given a retention test with a muscimol infusion followed by a recovery session. Muscimol infusions through cannula placements within 0.5 mm of the MGm prevented acquisition of eyeblink conditioned responses (CRs) and also blocked CR retention. Cannula placements more than 0.5 mm from the MATN did not completely block CR acquisition and had a partial effect on CR retention. The primary and secondary effects of MATN inactivation were examined with 2-deoxy-glucose (2-DG) autoradiography. Differences in 2-DG uptake in the auditory thalamus were consistent with the cannula placements and behavioral results. Differences in 2-DG uptake were found between groups in the ipsilateral auditory cortex, basilar pontine nuclei, and inferior colliculus. Results from this experiment indicate that the MATN contralateral to the trained eye and its projection to the pontine nuclei are necessary for acquisition and retention of eyeblink CRs to an auditory CS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.