Trial reportAnnals of family medicine
Integration of depression and hypertension treatment: a pilot, randomized controlled trial.
Trial report in Annals of family medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03426709 (Efficacy of a Blended Low Intensity Internet-delivered Psychological Program in Patients With Multimorbidity in Primary Care. A Randomized Clinical Trial.), which is not on this map. Cited by 70 papers, 18 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy of a Blended Low Intensity Internet-delivered Psychological Program in Patients With Multimorbidity in Primary Care. A Randomized Clinical Trial.
Who cites it
70 citing papers in PubMed, 18 syntheses or guidelines pooled it, 140 citations in OpenAlex.
- Healthcare interventions to improve health outcomes for racially/ethnic minoritised people with multiple long-term conditions: a systematic review and narrative synthesis.BMC public health · 2026Pooled it
- Specific content for collaborative care: a systematic review of collaborative care interventions for patients with multimorbidity involving depression and/or anxiety in primary care.Family practice · 2022Pooled it
- Interventions for improving outcomes in patients with multimorbidity in primary care and community settings.The Cochrane database of systematic reviews · 2021Pooled it
- The Effectiveness of Patient-Centred Medical Home-Based Models of Care versus Standard Primary Care in Chronic Disease Management: A Systematic Review and Meta-Analysis of Randomised and Non-Randomised Controlled Trials.International journal of environmental research and public health · 2020Pooled it
- Pooled it
- A systematic review of care management interventions targeting multimorbidity and high care utilization.BMC health services research · 2018Pooled it
- Identifying configurations of behavior change techniques in effective medication adherence interventions: a qualitative comparative analysis.Systematic reviews · 2016Pooled it
- Interventions for improving outcomes in patients with multimorbidity in primary care and community settings.The Cochrane database of systematic reviews · 2016Pooled it
- Pooled it
- Interventions to Improve Medication Adherence in Hypertensive Patients: Systematic Review and Meta-analysis.Current hypertension reports · 2015Pooled it
- Cultural relevance in medication adherence interventions with underrepresented adults: systematic review and meta-analysis of outcomes.Preventive medicine · 2014Pooled it
- Interventions for enhancing medication adherence.The Cochrane database of systematic reviews · 2014Pooled it
- Team-based care and improved blood pressure control: a community guide systematic review.American journal of preventive medicine · 2014Pooled it
- Improving adherence with medication: a selective literature review based on the example of hypertension treatment.Deutsches Arzteblatt international · 2014Pooled it
- Pooled it
- Collaborative care for depression and anxiety problems.The Cochrane database of systematic reviews · 2012Pooled it
- Managing patients with multimorbidity: systematic review of interventions in primary care and community settings.BMJ (Clinical research ed.) · 2012Pooled it
- Patient-Centered Outcomes of Medication Adherence Interventions: Systematic Review and Meta-Analysis.Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes ResearchPooled it
- Efficacy of a Blended Low-Intensity Internet-Delivered Psychological Program in Patients With Multimorbidity in Primary Care: Randomized Controlled Trial.Journal of medical Internet research · 2025Trial
- Evaluating the Impact of the Prime Time Sister CirclesJournal of general internal medicine · 2023Trial
10 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
purposeWe wanted to examine whether integrating depression treatment into care for hypertension improved adherence to antidepressant and antihypertensive medications, depression outcomes, and blood pressure control among older primary care patients.
methodsOlder adults prescribed pharmacotherapy for depression and hypertension from physicians at a large primary care practice in West Philadelphia were randomly assigned to an integrated care intervention or usual care. Outcomes were assessed at baseline, 2, 4, and 6 weeks using the Center for Epidemiologic Studies Depression Scale (CES-D) to assess depression, an electronic monitor to measure blood pressure, and the Medication Event Monitoring System to assess adherence.
resultsIn all, 64 participants aged 50 to 80 years participated. Participants in the integrated care intervention had fewer depressive symptoms (CES-D mean scores, intervention 9.9 vs usual care 19.3; P <.01), lower systolic blood pressure (intervention 127.3 mm Hg vs usual care 141.3 mm Hg; P <.01), and lower diastolic blood pressure (intervention 75.8 mm Hg vs usual care 85.0 mm Hg; P <.01) compared with participants in the usual care group at 6 weeks. Compared with the usual care group, the proportion of participants in the intervention group who had 80% or greater adherence to an antidepressant medication (intervention 71.9% vs usual care 31.3%; P <.01) and to an antihypertensive medication (intervention 78.1% vs usual care 31.3%; P <.001) was greater at 6 weeks.
conclusionA pilot, randomized controlled trial integrating depression and hypertension treatment was successful in improving patient outcomes. Integrated interventions may be more feasible and effective in real-world practices, where there are competing demands for limited resources.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.