ArticleProceedings of the National Academy of Sciences of the United States of America2008
Conserved T cell receptor alpha-chain induces insulin autoantibodies.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- Using the T Cell Receptor as a Biomarker in Type 1 Diabetes.Frontiers in immunology · 2021Review
- Understanding Autoimmune Diabetes through the Prism of the Tri-Molecular Complex.Frontiers in endocrinology · 2017Review
- Molecular Interactions Governing Autoantigen Presentation in Type 1 Diabetes.Current diabetes reports · 2015Review
- Monoclonal antibody blocking the recognition of an insulin peptide-MHC complex modulates type 1 diabetes.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Targeting the trimolecular complex.Clinical immunology (Orlando, Fla.) · 2013Review
- Pathogenic CD4⁺ T cells recognizing an unstable peptide of insulin are directly recruited into islets bypassing local lymph nodes.The Journal of experimental medicine · 2013Article
- George S. Eisenbarth: insulin and type 1 diabetes.Diabetes care · 2013Article
- Treg vaccination with a strong-agonistic insulin mimetope.Current diabetes reports · 2012Review
- Juvenile diabetes.The Indian journal of medical research · 2012Article
- T-cell receptor retrogenic mice: a rapid, flexible alternative to T-cell receptor transgenic mice.Immunology · 2012Review
- Paradigm shift or shifting paradigm for type 1 diabetes.Diabetes · 2012Article
- Germline TRAV5D-4 T-cell receptor sequence targets a primary insulin peptide of NOD mice.Diabetes · 2012Article
- Structure-based selection of small molecules to alter allele-specific MHC class II antigen presentation.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Specificity and detection of insulin-reactive CD4+ T cells in type 1 diabetes in the nonobese diabetic (NOD) mouse.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- The anti-insulin trimolecular complex in type 1 diabetes.Current opinion in endocrinology, diabetes, and obesity · 2010Review
- Gamma delta T cell receptors confer autonomous responsiveness to the insulin-peptide B:9-23.Journal of autoimmunity · 2010Article
- Review
- Banting Lecture 2009: An unfinished journey: molecular pathogenesis to prevention of type 1A diabetes.Diabetes · 2010Article
- Analysis of T cell receptor beta chains that combine with dominant conserved TRAV5D-4*04 anti-insulin B:9-23 alpha chains.Journal of autoimmunity · 2009Article
- Immunotherapy in autoimmune type 1 diabetes.The review of diabetic studies : RDSReview
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
A fundamental question is what are the molecular determinants that lead to spontaneous preferential targeting of specific autoantigens in autoimmune diseases, such as the insulin B:9-23 peptide sequence in type 1 diabetes. Anti-insulin B:9-23 T cell clones isolated from prediabetic NOD islets have a conserved Valpha-segment/Jalpha-segment, but no conservation of the alpha-chain N region and no conservation of the Vbeta-chain. Here, we show that the conserved T cell receptor alpha-chain generates insulin autoantibodies when transgenically or retrogenically introduced into mice without its corresponding Vbeta. We suggest that a major part of the mystery as to why islet autoimmunity develops relates to recognition of a primary insulin peptide by a conserved alpha chain T cell receptor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.