ArticleArchives of ophthalmology (Chicago, Ill. : 1960)2008
Rapid, noninvasive detection of diabetes-induced retinal metabolic stress.
Article in Archives of ophthalmology (Chicago, Ill. : 1960), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01676766 (Novel Quantification Methods for Fundus Flavoprotein Fluorescence and Lipofuscin Fluorescence to Detect Progression in Stargardt Disease), which is not on this map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Novel Quantification Methods for Fundus Flavoprotein Fluorescence and Lipofuscin Fluorescence to Detect Progression in Stargardt Disease
Who cites it
23 citing papers in PubMed, 47 citations in OpenAlex.
- Quantitative Flavoprotein Fluorescence Parameters in Retinal and Optic Nerve Diseases: A Scoping Review.Journal of clinical medicine · 2026Review
- Optic Disc Flavoprotein Fluorescence Imaging as a Novel Method to Quantify Disease Burden in Optic Disc Drusen.American journal of ophthalmology · 2026Article
- Flavoprotein Fluorescence Imaging in Stargardt Disease: Linking Metabolic Stress to Structural Damage.Investigative ophthalmology & visual science · 2025Article
- Flavoprotein fluorescence elevation is a marker of mitochondrial oxidative stress in patients with retinal disease.Frontiers in ophthalmology · 2023Article
- Discovery and clinical translation of novel glaucoma biomarkers.Progress in retinal and eye research · 2021Review
- Functional imaging of mitochondria in retinal diseases using flavoprotein fluorescence.Eye (London, England) · 2021Review
- Flavins Act as a Critical Liaison Between Metabolic Homeostasis and Oxidative Stress in the Retina.Frontiers in cell and developmental biology · 2020Review
- Imaging Retinal Ganglion Cell Death and Dysfunction in Glaucoma.International ophthalmology clinics · 2019Review
- Flavoprotein Fluorescence Correlation with Visual Acuity Response in Patients Receiving Anti-VEGF Injection for Diabetic Macular Edema.Oxidative medicine and cellular longevity · 2018Article
- Approach for a Clinically Useful Comprehensive Classification of Vascular and Neural Aspects of Diabetic Retinal Disease.Investigative ophthalmology & visual science · 2018Article
- Neurovascular cross talk in diabetic retinopathy: Pathophysiological roles and therapeutic implications.American journal of physiology. Heart and circulatory physiology · 2016Review
- Retinal Imaging Techniques for Diabetic Retinopathy Screening.Journal of diabetes science and technology · 2016Review
- Neuroprotection as a Therapeutic Target for Diabetic Retinopathy.Journal of diabetes research · 2016Review
- Diabetic Retinopathy and Diabetic Macular Edema.Developments in ophthalmology · 2016Review
- Optical quality of the diabetic eye: a review.Eye (London, England) · 2014Review
- Optical imaging of mitochondrial redox state in rodent model of retinitis pigmentosa.Journal of biomedical optics · 2013Article
- The bisretinoids of retinal pigment epithelium.Progress in retinal and eye research · 2012Review
- Retinal flavoprotein fluorescence correlates with mitochondrial stress, apoptosis, and chemokine expression.Experimental eye research · 2011Article
- The Optic UK Lecture: bench-to-bedside adventures of a diabetes researcher: results past, results present.Eye (London, England) · 2011Article
- Topographic and age-related changes of the retinal epithelium and Bruch's membrane of rhesus monkeys.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2010Article
Corrections and comments
- Commented on by
Authors and funding
9 authors.
Funding
Abstract
objectiveTo test whether subjects with diabetes mellitus (DM) have enhanced retinal flavoprotein autofluorescence compared with age-matched control subjects using a rapid, noninvasive clinical imaging method.
methodsTwenty-one subjects with DM and 21 healthy age-matched control volunteers were subjected to retinal imaging using 1-ms flashes of 467-nm light. Flavoprotein autofluorescence for each flash at 535 nm was recorded using an electron-multiplying charged-coupled device camera with a 512x512-pixel chip. The average intensity and the average curve width of retinal flavoprotein autofluorescence were determined by analyzing histograms of pixel intensities plotted for each eye.
resultsWhen stratified by age, the mean average intensity and average curve width levels in subjects with DM were significantly greater than those in controls across all 3 consecutive decades of life studied (P < or = .004 and P < or = .006, respectively). An overall comparison of the mean average intensity and average curve width levels in all subjects with DM vs all controls, with adjustment for age, was consistent with the results found in each age category (P =.001 and P < .001, respectively). Subjects having DM with retinopathy in at least 1 eye had significantly greater average intensity and average curve width than subjects having DM without retinopathy in either eye (P =.002 and P =.005, respectively).
conclusionsFlavoprotein autofluorescence measurements may be clinically useful to rapidly and noninvasively identify diabetic metabolic tissue stress and disease severity. Development of flavoprotein autofluorescence technology is likely to result in a tool that will improve DM screening and disease management.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.