ArticleThe Journal of cell biology2008
BRCA1 and Tip60 determine the cellular response to ultraviolet irradiation through distinct pathways.
Article in The Journal of cell biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 38 citations in OpenAlex.
- Nutlin-3 Loaded Ethosomes and Transethosomes to Prevent UV-Associated Skin Damage.Life (Basel, Switzerland) · 2024Article
- Loss of TIP60 (KAT5) abolishes H2AZ lysine 7 acetylation and causes p53, INK4A, and ARF-independent cell cycle arrest.Cell death & disease · 2022Article
- Acetylation of XPF by TIP60 facilitates XPF-ERCC1 complex assembly and activation.Nature communications · 2020Article
- Effect of Modified Wuzi Yanzong Pill () on Tip60-Mediated Apoptosis in Testis of Male Rats after Microwave Radiation.Chinese journal of integrative medicine · 2019Article
- B7-H3 promoted proliferation of mouse spermatogonial stem cellsOncotarget · 2018Article
- Article
- The Stress-responsive Gene ATF3 Mediates Dichotomous UV Responses by Regulating the Tip60 and p53 Proteins.The Journal of biological chemistry · 2016Article
- Mdm2 inhibition confers protection of p53-proficient cells from the cytotoxic effects of Wee1 inhibitors.Oncotarget · 2015Article
- Exploiting replicative stress to treat cancer.Nature reviews. Drug discovery · 2015Review
- Locus-specific control of DNA resection and suppression of subtelomeric VSG recombination by HAT3 in the African trypanosome.Nucleic acids research · 2014Article
- Preparation of (-)-Nutlin-3 using enantioselective organocatalysis at decagram scale.The Journal of organic chemistry · 2013Article
- Damage-induced DNA replication stalling relies on MAPK-activated protein kinase 2 activity.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Deubiquitination of Tip60 by USP7 determines the activity of the p53-dependent apoptotic pathway.Molecular and cellular biology · 2013Article
- Nutlin-3a, an MDM2 antagonist and p53 activator, helps to preserve the replicative potential of cancer cells treated with a genotoxic dose of resveratrol.Molecular biology reports · 2013Article
- UV-C irradiation delays mitotic progression by recruiting Mps1 to kinetochores.Cell cycle (Georgetown, Tex.) · 2013Article
- Connecting chromatin modifying factors to DNA damage response.International journal of molecular sciences · 2013Article
- The chromatin remodeling protein BRG1 modulates BRCA1 response to UV irradiation by regulating ATR/ATM activation.Frontiers in oncology · 2013Article
- Two strategies for the development of mitochondrion-targeted small molecule radiation damage mitigators.International journal of radiation oncology, biology, physics · 2011Article
- PI 3 kinase related kinases-independent proteolysis of BRCA1 regulates Rad51 recruitment during genotoxic stress in human cells.PloS one · 2010Article
- MDM2 mediates ubiquitination and degradation of activating transcription factor 3.The Journal of biological chemistry · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The histone acetyltransferase Tip60 regulates the apoptotic response to ultraviolet (UV) irradiation. A previously suggested mechanism for this regulation consists of the ability of Tip60 to coactivate transcription by the tumor suppressor p53. In this study, we show that Tip60 is required for the early DNA damage response (DDR) to UV, including the phosphorylation of histone 2AX, c-Jun N-terminal kinases (JNKs), and ataxia telangiectasia-related substrates. In contrast, p53 was not required for UV-induced DDR. Rather, p53 accumulation by either knockdown of Mdm2 or addition of an Mdm2 inhibitor, Nutlin-3, before irradiation strongly attenuated the UV-induced DDR and increased cell survival. This protective effect of preaccumulated p53 was mediated, at least in part, by the increased expression of CDKN1A/p21, subsequent down-regulation of BRCA1, and impaired JNK activation accompanied by decreased association of replication protein A with chromatin. We conclude that Tip60 enables UV-induced DDR signaling even in the absence of p53, whereas preaccumulated p53 suppresses UV-induced DDR by reducing the levels of BRCA1.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.