ArticleJournal of aging and health2008
Assessing multiple medication use with probabilities of benefits and harms.
Article in Journal of aging and health, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Ex Ante Economic Evaluation of Arg389 Genetically Targeted Treatment with Bucindolol versus Empirical Treatment with Carvedilol in NYHA III/IV Heart Failure.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2021Article
- Association between Statin Use and Balance in Older Adults.International journal of environmental research and public health · 2020Article
- Medication appropriateness criteria for older adults: a narrative review of criteria and supporting studies.Therapeutic advances in drug safety · 2019Review
- Reporting actionable research results: shared secrets can save lives.Science translational medicine · 2012Article
- Patterns and predictors of recovery from exhaustion in older adults: the cardiovascular health study.Journal of the American Geriatrics Society · 2011Article
- Primary care clinicians' experiences with treatment decision making for older persons with multiple conditions.Archives of internal medicine · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
objectiveA quantitative framework to assess harms and benefits of candidate medications in the context of drugs that a patient is already taking is proposed.
methodProbabilities of harms and benefits of a given medication are averaged to yield a utility value. The utility values of all medications under consideration are combined as a geometric mean to yield an overall measure of favorability. The grouping of medications yielding the highest favorability value is chosen.
resultsFive examples of choosing between widely used candidate medications demonstrate the feasibility of the proposed framework. DISCUSSION: The framework proposed provides a simple method for considering the trade-offs involved in prescribing multiple medications. It can be adapted to include additional parameters representing severity of condition, prioritization of outcomes, patient preferences, dosages, and medication interactions. Inconsistent reporting in the medical literature of data about benefits and harms of medications, dosages, and interactions constitutes its primary limitation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.