ArticleInfection and immunity2008
Characteristics of biofilm formation by Streptococcus mutans in the presence of saliva.
Article in Infection and immunity, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
91 citing papers in PubMed, 1 synthesis or guideline pooled it, 171 citations in OpenAlex.
- Key virulence genes associated withFrontiers in oral health · 2025Pooled it
- Morphological changes in Streptococcus mutans after chewing gum containing xylitol for twelve months.Current microbiology · 2009Trial
- Article
- Genomic and phenotypic insights into the novel speciesMicrobiology spectrum · 2026Article
- An Innovative Oral Ex Vivo Biofilm Model for Antimicrobial Investigations.Pathogens (Basel, Switzerland) · 2026Article
- Anti-Cariogenic Effect of Trans-Cinnamaldehyde in an In Vitro Mouse Jaw Explant Model.Pharmaceuticals (Basel, Switzerland) · 2026Article
- A zinc-free alternative ribosomal protein RpsN.2 confers survival advantage to group A streptococcus during Zn scarcity.Infection and immunity · 2025Article
- The butterfly effect: collateral damage and impacts of antimicrobial strategies on the oral microbiome.npj antimicrobials and resistance · 2025Review
- Biofilms and oral health: nanotechnology for biofilm control.Discover nano · 2025Review
- Antimicrobial Peptide P-113-DPS Suppresses the Cariogenic Virulence ofACS applied bio materials · 2025Article
- Optimizing of photodynamic parameters: determining the key factors for effective inactivation of Streptococcus mutans biofilms with phycocyanin.Lasers in medical science · 2025Article
- Dental plaque-inspired peptide engineered to control plaque accumulation.Materials today. Bio · 2025Article
- Glycosylation of oral bacteria in modulating adhesion and biofilm formation.Journal of oral microbiology · 2025Review
- Effects of 3'-sialyllactose, saliva, and colostrum on Candida albicans biofilms.Einstein (Sao Paulo, Brazil) · 2025Article
- Glucosyltransferase activity-based screening identifies tannic acid as an inhibitor ofFrontiers in microbiology · 2025Article
- Selective Biofilm Inhibition through Mucin-Inspired Engineering of Silk Glycopolymers.Journal of the American Chemical Society · 2024Article
- Small cyclic dipeptide produced byBiofilm · 2024Article
- Adhesive interactions within microbial consortia can be differentiated at the single-cell level through expansion microscopy.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Influence of Polymerization Protocol on Adhesion and Proliferation ofBiomedicines · 2024Article
- Adhesive interactions within microbial consortia can be differentiated at the single-cell level through expansion microscopy.bioRxiv : the preprint server for biology · 2024Article
31 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 2 countries.
Funding
Abstract
Interactions between salivary agglutinin and the adhesin P1 of Streptococcus mutans contribute to bacterial aggregation and mediate sucrose-independent adherence to tooth surfaces. We have examined biofilm formation by S. mutans UA159, and derivative strains carrying mutations affecting the localization or expression of P1, in the presence of fluid-phase or adsorbed saliva or salivary agglutinin preparations. Whole saliva- and salivary agglutinin-induced aggregation of S. mutans was adversely affected by the loss of P1 and sortase (SrtA) but not by the loss of trigger factor (RopA). Fluid-phase salivary agglutinin and, to a lesser extent, immobilized agglutinin inhibited biofilm development by S. mutans in the absence of sucrose, and whole saliva was more effective at decreasing biofilm formation than salivary agglutinin. Inhibition of biofilm development by salivary agglutinin was differently influenced by particular mutations, with the P1-deficient strain displaying a greater inhibition of biofilm development than the SrtA- or RopA-deficient strains. As expected, biofilm-forming capacities of all strains in the presence of salivary preparations were markedly enhanced in the presence of sucrose, although biofilm formation by the mutants was less efficient than that by the parental strain. Aeration strongly inhibited biofilm development, and the presence of salivary components did not restore biofilm formation in aerated conditions. The results disclose a potent ability of salivary constituents to moderate biofilm formation by S. mutans through P1-dependent and P1-independent pathways.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.