ArticleMolecular and cellular biology2008
A novel Tel1/ATM N-terminal motif, TAN, is essential for telomere length maintenance and a DNA damage response.
Article in Molecular and cellular biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 24 citations in OpenAlex.
- Tel1 is recruited at chromosomal loop/axis contact sites to modulate meiotic DNA double-strand breaks interference.PLoS genetics · 2025Article
- Ataxia Telangiectasia-Mutated Is Activated but Not Required for Productive Autographa californica Multiple Nucleopolyhedrovirus Infection.Journal of virology · 2022Article
- Molecular basis of human ATM kinase inhibition.Nature structural & molecular biology · 2021Article
- Pathogenic genetic variants from highly connected cancer susceptibility genes confer the loss of structural stability.Scientific reports · 2021Article
- Unpicking the Roles of DNA Damage Protein Kinases in Trypanosomatids.Frontiers in cell and developmental biology · 2021Review
- Progress towards a clinically-successful ATR inhibitor for cancer therapy.Current research in pharmacology and drug discovery · 2021Review
- ATM Dysfunction in Pancreatic Adenocarcinoma and Associated Therapeutic Implications.Molecular cancer therapeutics · 2019Review
- Article
- ATM, radiation, and the risk of second primary breast cancer.International journal of radiation biology · 2017Review
- Structures of closed and open conformations of dimeric human ATM.Science advances · 2017Article
- The Dimeric Architecture of Checkpoint Kinases Mec1ATR and Tel1ATM Reveal a Common Structural Organization.The Journal of biological chemistry · 2016Article
- The atm-1 gene is required for genome stability in Caenorhabditis elegans.Molecular genetics and genomics : MGG · 2012Article
- ATM protein kinase: the linchpin of cellular defenses to stress.Cellular and molecular life sciences : CMLS · 2011Review
- Activation of protein kinase Tel1 through recognition of protein-bound DNA ends.Molecular and cellular biology · 2011Article
- Multiple roles of ATM in monitoring and maintaining DNA integrity.FEBS letters · 2010Review
- An mre11 mutation that promotes telomere recombination and an efficient bypass of senescence.Genetics · 2010Article
- Mec1 function in the DNA damage response does not require its interaction with Tel2.Cell cycle (Georgetown, Tex.) · 2008Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Tel1/ATM, a conserved phosphatidylinositol 3-kinase-related kinase (PIKK), acts in the response to DNA damage and regulates telomere maintenance. PIKK family members share an extended N-terminal region of low sequence homology. Sequence alignment of the N terminus of Tel1/ATM orthologs revealed a conserved, novel motif we term TAN (for Tel1/ATM N-terminal motif). Point mutations in conserved residues of the TAN motif resulted in telomere shortening, and its deletion caused the same short telomere phenotype as complete deletion of Tel1 did. Overexpressing Tel1 TAN mutants did not rescue telomere shortening. The TAN motif was also essential for the function of Tel1 in the response to DNA damage, as TAN-deleted Tel1 was indistinguishable from the complete lack of Tel1 in causing reduced viability and signaling through Rad53 upon DNA damage. Strikingly, TAN deletion reduced recruitment of Tel1 to a double-strand DNA break. Together, these results define a conserved sequence motif within an otherwise poorly defined region of the Tel1/ATM kinase family proteins that is essential for normal Tel1 function in Saccharomyces cerevisiae.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.