ArticleThe Journal of biological chemistry2008
Protein kinase R-dependent regulation of interleukin-10 in response to double-stranded RNA.
Article in The Journal of biological chemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- An NF-kB/TNF-alpha signalling feedback loop acts to coordinate tissue regeneration and macrophage behaviour in zebrafish.NPJ Regenerative medicine · 2025Article
- The immune response to RNA suppresses nucleic acid synthesis by limiting ribose 5-phosphate.The EMBO journal · 2024Article
- PKR induces TGF-β and limits oncolytic immune therapy.Journal for immunotherapy of cancer · 2023Article
- Biology and therapeutic potential of interleukin-10.The Journal of experimental medicine · 2020Review
- Evidence for dispensability of protein kinase R in host control of tuberculosis.European journal of immunology · 2018Article
- PKR: A Kinase to Remember.Frontiers in molecular neuroscience · 2018Review
- IL-10-mediated signals act as a switch for lymphoproliferation in Human T-cell leukemia virus type-1 infection by activating the STAT3 and IRF4 pathways.PLoS pathogens · 2017Article
- Article
- The atypical IκB protein IκB(NS) is important for Toll-like receptor-induced interleukin-10 production in B cells.Immunology · 2016Article
- Identification of 10 cowpox virus proteins that are necessary for induction of hemorrhagic lesions (red pocks) on chorioallantoic membranes.Journal of virology · 2014Article
- PKR mediated regulation of inflammation and IL-10 during viral encephalomyelitis.Journal of neuroimmunology · 2014Article
- Article
- Epigenomic elements enriched in the promoters of autoimmunity susceptibility genes.Epigenetics · 2014Article
- The protein kinase double-stranded RNA-dependent (PKR) enhances protection against disease cause by a non-viral pathogen.PLoS pathogens · 2013Article
- Inhibition of JAKs in macrophages increases lipopolysaccharide-induced cytokine production by blocking IL-10-mediated feedback.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Role of interleukin 10 transcriptional regulation in inflammation and autoimmune disease.Critical reviews in immunology · 2012Review
- Improved control of tuberculosis and activation of macrophages in mice lacking protein kinase R.PloS one · 2012Article
- The regulation of IL-10 production by immune cells.Nature reviews. Immunology · 2010Review
- Article
- Vaccinia virus E3 suppresses expression of diverse cytokines through inhibition of the PKR, NF-kappaB, and IRF3 pathways.Journal of virology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
The double-stranded RNA-activated protein kinase R (PKR) is an important component of antiviral defense. PKR participates in different signaling pathways in response to various stimuli to regulate translation via phosphorylation of the eukaryotic initiation factor 2alpha, and transcription via activating NF-kappaB and IRF-1, to induce pro-inflammatory cytokines. Here we show PKR regulates interleukin-10 induction in response to double-stranded RNA, bacterial lipopolysaccaride, and Sendai virus infection. Using chemical inhibitors, dominant negative constructs, and genetic knockouts, we demonstrate that the PKR-mediated interleukin-10 induction engages JNK and NF-kappaB. Together, our data demonstrate the role of PKR in regulating an anti-inflammatory cytokine. The findings have significance in antiviral as well as broader innate immune responses.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.