ArticleMolecular and cellular neurosciences2009
Expanded CAG repeats in the murine Huntington's disease gene increases neuronal differentiation of embryonic and neural stem cells.
Article in Molecular and cellular neurosciences, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 29 citations in OpenAlex.
- Exploring huntington's disease from a neurodevelopmental perspective.International journal of biological sciences · 2026Review
- SpateCV: cross-modality alignment regularization of cell types improves spatial gene imputation for spatial transcriptomics.Journal of translational medicine · 2025Article
- Intersecting impact of CAG repeat and huntingtin knockout in stem cell-derived cortical neurons.Neurobiology of disease · 2025Article
- Human striatal organoids derived from pluripotent stem cells recapitulate striatal development and compartments.PLoS biology · 2022Article
- A Progressive Loss of phosphoSer138-Profilin Aligns with Symptomatic Course in the R6/2 Mouse Model of Huntington's Disease: Possible Sex-Dependent Signaling.Cellular and molecular neurobiology · 2022Article
- From Progenitors to Progeny: Shaping Striatal Circuit Development and Function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Review
- Huntington Disease as a Neurodevelopmental Disorder and Early Signs of the Disease in Stem Cells.Molecular neurobiology · 2018Review
- Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice.Nature neuroscience · 2017Article
- Huntingtin Is Required for Neural But Not Cardiac/Pancreatic Progenitor Differentiation of Mouse Embryonic Stem CellsFrontiers in cellular neuroscience · 2017Article
- Selective expression of mutant huntingtin during development recapitulates characteristic features of Huntington's disease.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Transcription, epigenetics and ameliorative strategies in Huntington's Disease: a genome-wide perspective.Molecular neurobiology · 2015Review
- Article
- Modeling Huntington's disease with induced pluripotent stem cells.Molecular and cellular neurosciences · 2013Review
- Extensive changes in DNA methylation are associated with expression of mutant huntingtin.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Selective roles of normal and mutant huntingtin in neural induction and early neurogenesis.PloS one · 2013Article
- A broad phenotypic screen identifies novel phenotypes driven by a single mutant allele in Huntington's disease CAG knock-in mice.PloS one · 2013Article
- Huntington's disease and its therapeutic target genes: a global functional profile based on the HD Research Crossroads database.BMC neurology · 2012Article
- Multiple phenotypes in Huntington disease mouse neural stem cells.Molecular and cellular neurosciences · 2012Article
- Targeting Huntington's disease through histone deacetylases.Clinical epigenetics · 2011Article
- Inflammation mediates varying effects in neurogenesis: relevance to the pathogenesis of brain injury and neurodegenerative disorders.Journal of neurochemistry · 2009Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Huntington's disease is an uncommon autosomal dominant neurodegenerative disorder caused by expanded polyglutamine repeats. Increased neurogenesis was demonstrated recently in Huntington's disease post-mortem samples. In this manuscript, neuronally differentiated embryonic stem cells with expanded CAG repeats in the murine Huntington's disease homologue and neural progenitors isolated from the subventricular zone of an accurate mouse Huntington's disease were examined for increased neurogenesis. Embryonic stem cells with expanded CAG repeats in the murine Huntington's disease homologue were demonstrated to undergo facilitated differentiation first into neural progenitors, then into more mature neurons. Neural progenitor cells isolated from the subventricular zone of a Huntington's disease knock-in animal displayed increased production of neural progenitors and increased neurogenesis. These findings suggested that neuronally differentiating embryonic stem cells with expanded CAG repeats is a reasonable system to identify factors responsible for increased neurogenesis in Huntington's disease. Expression profiling analysis comparing neuronally differentiating embryonic stem cells with expanded CAG repeats to neuronally differentiating embryonic stem cells without expanded CAG repeats identified transcripts involved in development and transcriptional regulation as factors possibly mediating increased neurogenesis in response to expanded CAG repeats.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.