ArticleBiochemical and biophysical research communications2008
Dissecting the regulation of yeast genes by the osmotin receptor.
Article in Biochemical and biophysical research communications, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed.
- ROS Dependent Antifungal and Anticancer Modulations ofMolecules (Basel, Switzerland) · 2021Article
- Osmotin: a plant sentinel and a possible agonist of mammalian adiponectin.Frontiers in plant science · 2015Review
- The polyene antifungals, amphotericin B and nystatin, cause cell death in Saccharomyces cerevisiae by a distinct mechanism to amphibian-derived antimicrobial peptides.Annals of clinical microbiology and antimicrobials · 2014Article
- A Saccharomyces cerevisiae assay system to investigate ligand/AdipoR1 interactions that lead to cellular signaling.PloS one · 2013Article
- Characterization and ligand identification of a membrane progesterone receptor in fungi: existence of a novel PAQR in Sporothrix schenckii.BMC microbiology · 2012Article
- Phylogenetic and preliminary phenotypic analysis of yeast PAQR receptors: potential antifungal targets.Journal of molecular evolution · 2011Article
- Overexpression of osmotin gene confers tolerance to salt and drought stresses in transgenic tomato (Solanum lycopersicum L.).Protoplasma · 2010Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The Izh2p protein from Saccharomyces cerevisiae is a receptor for the plant antifungal protein, osmotin. Since Izh2p is conserved in fungi, understanding its biochemical function could inspire novel strategies for the prevention of fungal growth. However, it has been difficult to determine the exact role of Izh2p because it has pleiotropic effects on cellular biochemistry. Herein, we demonstrate that Izh2p negatively regulates functionally divergent genes through a CCCTC promoter motif. Moreover, we show that Izh2p-dependent promoters containing this motif are regulated by the Nrg1p/Nrg2p and Msn2p/Msn4p transcription factors. The fact that Izh2p can regulate gene expression through this widely dispersed element presents a reasonable explanation of its pleiotropy. The involvement of Nrg1p/Nrgp2 in Izh2p-dependent gene regulation also suggests a role for this receptor in regulating fungal differentiation in response to stimuli produced by plants.
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Registered trials
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