ReviewCurrent diabetes reports2008
Genes and type 2 diabetes mellitus.
Review in Current diabetes reports, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pathophysiology of Type 2 Diabetes in Children and Adolescents.Current diabetes reviews · 2020Pooled it
- Family history of diabetes and glycemic progression: A propensity score-based analysis using health checkup data.PloS one · 2026Article
- Oral antidiabetic therapy versus early insulinization on glycemic control in newly diagnosed type 2 diabetes patients: a retrospective matched cohort study.Scientific reports · 2024Article
- Comments on: Lack of association between fat mass and obesity-associated genetic variant (rs8050136) and type 2 diabetes mellitus.Saudi medical journal · 2022Article
- "H" for Heterogeneity in the Algorithm for Type 2 Diabetes Management.Current diabetes reports · 2020Review
- Neurons and Microglia; A Sickly-Sweet Duo in Diabetic Pain Neuropathy.Frontiers in neuroscience · 2019Review
- The Effects of Breakfast Consumption and Composition on Metabolic Wellness with a Focus on Carbohydrate Metabolism.Advances in nutrition (Bethesda, Md.) · 2016Review
- Insulin receptor substrate-1 (IRS-1) Gly927Arg: correlation with gestational diabetes mellitus in Saudi women.BioMed research international · 2014Article
- Pathophysiologic approach to therapy in patients with newly diagnosed type 2 diabetes.Diabetes care · 2013 · on this mapArticle
- Beyond single-marker analyses: mining whole genome scans for insights into treatment responses in severe sepsis.The pharmacogenomics journal · 2013Article
- Islet-enriched gene expression and glucose-induced insulin secretion in human and mouse islets.Diabetologia · 2012Article
- Type 2 diabetes risk alleles demonstrate extreme directional differentiation among human populations, compared to other diseases.PLoS genetics · 2012Article
- Clinically-Defined Maturity Onset Diabetes of the Young in Omanis: Absence of the common Caucasian gene mutations.Sultan Qaboos University medical journal · 2010Article
- Mexican-American admixture mapping analyses for diabetic nephropathy in type 2 diabetes mellitus.Seminars in nephrology · 2010Article
- Goals of treatment for type 2 diabetes: beta-cell preservation for glycemic control.Diabetes care · 2009Review
- Insulin resistance versus beta-cell dysfunction in the pathogenesis of type 2 diabetes.Current diabetes reports · 2009 · on this mapArticle
- Glutaredoxin-1 mediates NADPH-dependent stimulation of calcium-dependent insulin secretion.Molecular endocrinology (Baltimore, Md.) · 2009Article
- Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus.Diabetes · 2009 · on this mapArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In 2007, five whole genome-wide association studies were published on the genetics of type 2 diabetes mellitus (T2DM), followed by the discovery of 11 genes consistently associated with T2DM. This breakthrough provided the first glimpses of a complete picture of the disease's genetic complexity. Currently, we are only beginning to understand how DNA methylation, histone acetylation, and deacetylation may introduce epigenetic changes throughout one's lifetime. Such changes may influence age-related modifications in gene-expression that contribute to age-related diseases. In the future, the possibility of whole-genome DNA methylation studies may elucidate the extent of these epigenetic effects. This article reviews genes that have recently been determined to be associated with T2DM.
Indexed as
Identifiers
18625115What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.