ArticleBMC pulmonary medicine2008
Surfactant replacement and open lung concept--comparison of two treatment strategies in an experimental model of neonatal ARDS.
Article in BMC pulmonary medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 9 citations in OpenAlex.
- Endotracheal Surfactant Combined With Budesonide for Neonatal ARDS.Frontiers in pediatrics · 2020Article
- The porcine innate immune system: an update.Developmental and comparative immunology · 2014Review
- In vivo effect of pneumonia on surfactant disaturated-phosphatidylcholine kinetics in newborn infants.PloS one · 2014Article
- Surfactant use based on the oxygenation response to lung recruitment during HFOV in VLBW infants.Intensive care medicine · 2010Article
- A pumpless lung assist device reduces mechanical ventilation-induced lung injury in juvenile piglets.Pediatric research · 2009Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSeveral concepts of treatment in neonatal ARDS have been proposed in the last years. The present study compared the effects of open lung concept positive pressure ventilation (PPVOLC) with a conventional ventilation strategy combined with administration of two different surfactant preparations on lung function and surfactant homoeostasis.
methodsAfter repeated whole-lung saline lavage, 16 newborn piglets were assigned to either PPVOLC (n = 5) or surfactant treatment under conventional PPV using a natural bovine (n = 5) or a monomeric protein B based surfactant (n = 6).
resultsComprehensive monitoring showed each treatment strategy to improve gas exchange and lung function, although the effect on PaO2 and pulmonary compliance declined over the study period in the surfactant groups. The overall improvement of the ventilation efficiency index (VEI) was significantly greater in the PPVOLC group. Phospholipid and protein analyses of the bronchoalveolar lavage fluid showed significant alterations to surfactant homoeostasis in the PPVOLC group, whereas IL-10 and SP-C mRNA expression was tendentially increased in the surfactant groups.
conclusionThe different treatment strategies applied could be shown to improve gas exchange and lung function in neonatal ARDS. To which extent differences in maintenance of lung function and surfactant homeostasis may lead to long-term consequences needs to be studied further.
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