ArticleBMC veterinary research2008
Prevalence of the prion protein gene E211K variant in U.S. cattle.
Article in BMC veterinary research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 53 citations in OpenAlex.
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- Continuous chromosome-scale haplotypes assembled from a single interspecies F1 hybrid of yak and cattle.GigaScience · 2020Article
- Evaluation ofF1000Research · 2019Article
- The first report of polymorphisms and genetic characteristics of the prion protein gene (PRNP) in horses.Prion · 2018Article
- A bovine CD18 signal peptide variant with increased binding activity toF1000Research · 2018Article
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- Using diverse U.S. beef cattle genomes to identify missense mutations inF1000Research · 2016Article
- A Review of Selected Genes with Known Effects on Performance and Health of Cattle.Frontiers in veterinary science · 2016Review
- A Comparison of Classical and H-Type Bovine Spongiform Encephalopathy Associated with E211K Prion Protein Polymorphism in Wild-Type and EK211 Cattle Following Intracranial Inoculation.Frontiers in veterinary science · 2016Article
- Genetics of Prion Disease in Cattle.Bioinformatics and biology insights · 2015Review
- Genetic diversity in the prion protein gene (PRNP) of domestic cattle and water buffaloes in Vietnam, Indonesia and Thailand.The Journal of veterinary medical science · 2014Article
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- Discriminant analysis of prion sequences for prediction of susceptibility.Experimental & molecular medicine · 2013Article
- Mapping whole genome shotgun sequence and variant calling in mammalian species without their reference genomes.F1000Research · 2013Article
- Sequence variations of the bovine prion protein gene (PRNP) in native Korean Hanwoo cattle.Journal of veterinary science · 2012Article
- Genetic variability of the coding region for the prion protein gene (PRNP) in gayal (Bos frontalis).Molecular biology reports · 2012Article
- An overview of animal prion diseases.Virology journal · 2011Review
- Conserved properties of human and bovine prion strains on transmission to guinea pigs.Laboratory investigation; a journal of technical methods and pathology · 2011Article
Corrections and comments
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Authors and funding
17 authors at 6 institutions in 1 country.
Funding
Abstract
backgroundIn 2006, an atypical U.S. case of bovine spongiform encephalopathy (BSE) was discovered in Alabama and later reported to be polymorphic for glutamate (E) and lysine (K) codons at position 211 in the bovine prion protein gene (Prnp) coding sequence. A bovine E211K mutation is important because it is analogous to the most common pathogenic mutation in humans (E200K) which causes hereditary Creutzfeldt - Jakob disease, an autosomal dominant form of prion disease. The present report describes a high-throughput matrix-associated laser desorption/ionization-time-of-flight mass spectrometry assay for scoring the Prnp E211K variant and its use to determine an upper limit for the K211 allele frequency in U.S. cattle.
resultsThe K211 allele was not detected in 6062 cattle, including those from five commercial beef processing plants (3892 carcasses) and 2170 registered cattle from 42 breeds. Multiple nearby polymorphisms in Prnp coding sequence of 1456 diverse purebred cattle (42 breeds) did not interfere with scoring E211 or K211 alleles. Based on these results, the upper bounds for prevalence of the E211K variant was estimated to be extremely low, less than 1 in 2000 cattle (Bayesian analysis based on 95% quantile of the posterior distribution with a uniform prior).
conclusionNo groups or breeds of U.S. cattle are presently known to harbor the Prnp K211 allele. Because a carrier was not detected, the number of additional atypical BSE cases with K211 will also be vanishingly low.
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