ArticleJournal of neurochemistry2008
Premature centromere division of the X chromosome in neurons in Alzheimer's disease.
Article in Journal of neurochemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 43 citations in OpenAlex.
- Assessment of X Chromosome Centromere Instability in Alzheimer's Disease: A Quantitative FISH Approach.Current issues in molecular biology · 2025Article
- Assessment of Chromosomal Aberrations and S-phase Fraction in Patients With Esophageal Cancer.Cureus · 2025Article
- Sex-based differences in effector cells of the adaptive immune system during Alzheimer's disease and related dementias.Neurobiology of disease · 2023Review
- Satellite DNAs and human sex chromosome variation.Seminars in cell & developmental biology · 2022Review
- Unraveling the links between neurodegeneration and Epstein-Barr virus-mediated cell cycle dysregulation.Current research in neurobiology · 2022Review
- Sex Differences in Alzheimer's Disease: Insights From the Multiomics Landscape.Biological psychiatry · 2022Review
- Core cell cycle machinery is crucially involved in both life and death of post-mitotic neurons.Cellular and molecular life sciences : CMLS · 2020Review
- Pathological Aspects of Neuronal Hyperploidization in Alzheimer's Disease Evidenced by Computer Simulation.Frontiers in genetics · 2020Article
- Biological Hallmarks of Cancer in Alzheimer's Disease.Molecular neurobiology · 2019Review
- The X Files: "The Mystery of X Chromosome Instability in Alzheimer's Disease".Frontiers in genetics · 2019Review
- Role of Trisomy 21 Mosaicism in Sporadic and Familial Alzheimer's Disease.Current Alzheimer research · 2016Review
- X chromosome aneuploidy in the Alzheimer's disease brain.Molecular cytogenetics · 2014Article
- Mislocalization of CDK11/PITSLRE, a regulator of the G2/M phase of the cell cycle, in Alzheimer disease.Cellular & molecular biology letters · 2011Article
- Cell cycle deregulation in the neurons of Alzheimer's disease.Results and problems in cell differentiation · 2011Review
- Premature centromere division of metaphase chromosomes in peripheral blood lymphocytes of Alzheimer's disease patients: relation to gender and age.The journals of gerontology. Series A, Biological sciences and medical sciences · 2010Article
- Pathological implications of cell cycle re-entry in Alzheimer disease.Expert reviews in molecular medicine · 2010Review
- Review: cell cycle aberrations and neurodegeneration.Neuropathology and applied neurobiology · 2010Review
- Biomarkers in Alzheimer's disease: past, present and future.Biomarkers in medicine · 2010Review
- The X-chromosome instability phenotype in Alzheimer's disease: a clinical sign of accelerating aging?Medical hypotheses · 2009Article
- Cell cycle re-entry mediated neurodegeneration and its treatment role in the pathogenesis of Alzheimer's disease.Neurochemistry international · 2009Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Premature centromere division (PCD) represents a loss of control over the sequential separation and segregation of chromosome centromeres. Although first described in aging women, PCD on the X chromosome (PCD,X) is markedly elevated in peripheral blood lymphocytes of individuals suffering from Alzheimer disease (AD). The present study evaluated PCD,X, using a fluorescent in situ hybridization method, in interphase nuclei of frontal cerebral cortex neurons from sporadic AD patients and age-matched controls. The average frequency of PCD,X in AD patients (8.60 +/- 1.20%) was almost three times higher (p < 0.01) than in the control group (2.96 +/- 1.20). However, consistent with previous studies, no mitotic cells were found in neurons in either AD or control brain, suggesting an intrinsic inability of post-mitotic neurons to divide. In view of the fact that it has been well-documented that neurons in AD can re-enter into the cell division cycle, the findings presented here of increased PCD advance the hypothesis that deregulation of the cell cycle may contribute to neuronal degeneration and subsequent cognitive deficits in AD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.