ArticleJournal of anatomy2008
An in situ hybridization study of Runx2, Osterix, and Sox9 in the anlagen of mouse mandibular condylar cartilage in the early stages of embryogenesis.
Article in Journal of anatomy, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 43 citations in OpenAlex.
- Biomechanical strain patterns in Meckel's cartilage underlie mandibular variation in FGFR2 mouse models.Anatomical record (Hoboken, N.J. : 2007) · 2026Article
- Qiang Jin Mixture Promotes Osteogenic Differentiation of MC3T3-E1 Cells via BMP2/Smads Pathway and its Network Pharmacology Study.Molecular biotechnology · 2025Article
- Lgr5-expressing secretory cells form a Wnt inhibitory niche in cartilage critical for chondrocyte identity.Cell stem cell · 2023Article
- Evolution and development of the mammalian jaw joint: Making a novel structure.Evolution & development · 2023Review
- Meckel's Cartilage in Mandibular Development and Dysmorphogenesis.Frontiers in genetics · 2022Article
- Evidence of vasculature and chondrocyte to osteoblast transdifferentiation in craniofacial synovial joints: Implications for osteoarthritis diagnosis and therapy.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- Sox9+ messenger cells orchestrate large-scale skeletal regeneration in the mammalian rib.eLife · 2019Article
- Deletion of Menin in craniofacial osteogenic cells in mice elicits development of mandibular ossifying fibroma.Oncogene · 2018Article
- Augmented Indian hedgehog signaling in cranial neural crest cells leads to craniofacial abnormalities and dysplastic temporomandibular joint in mice.Cell and tissue research · 2016Article
- An in situ hybridization study of perlecan, DMP1, and MEPE in developing condylar cartilage of the fetal mouse mandible and limb bud cartilage.European journal of histochemistry : EJH · 2015Article
- Progenitor Cells of the Mandibular Condylar Cartilage.Current molecular biology reports · 2015Article
- Overexpression of Indian hedgehog partially rescues short stature homeobox 2-overexpression-associated congenital dysplasia of the temporomandibular joint in mice.Molecular medicine reports · 2015Article
- Osterix couples chondrogenesis and osteogenesis in post-natal condylar growth.Journal of dental research · 2014Article
- Overexpression of Shox2 leads to congenital dysplasia of the temporomandibular joint in mice.International journal of molecular sciences · 2014Article
- An immunohistochemical study of matrix proteins in the craniofacial cartilage in midterm human fetuses.European journal of histochemistry : EJH · 2013Article
- Dentin sialophosphoprotein (DSPP) plays an essential role in the postnatal development and maintenance of mouse mandibular condylar cartilage.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2013Article
- An immunohistochemistry study of Sox9, Runx2, and Osterix expression in the mandibular cartilages of newborn mouse.BioMed research international · 2013Article
- An in situ hybridization study of the insulin-like growth factor system in developing condylar cartilage of the fetal mouse mandible.European journal of histochemistry : EJH · 2012Article
- Tissue interaction is required for glenoid fossa development during temporomandibular joint formation.Developmental dynamics : an official publication of the American Association of Anatomists · 2011Article
- Mesenchymal and mechanical mechanisms of secondary cartilage induction.Developmental biology · 2011Article
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Authors and funding
2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Mandibular condylar cartilage is the best-studied mammalian secondary cartilage, differing from primary cartilage in that it originates from alkaline phosphatase-positive progenitor cells. We previously demonstrated that three transcription factors related to bone and cartilage formation, namely Runx2, Osterix and Sox9, are simultaneously expressed in the anlage of mandibular condylar cartilage (condylar anlage) at embryonic day (E)14. In this study, expression of these transcription factors was investigated in the anlagen of mandibular bone (mandibular anlagen) from E11.0 to 14.0. Runx2 mRNA was first expressed in the mandibular anlage at E11.5. Osterix mRNA was first expressed at E12.0, and showed a different expression pattern from that of Runx2 from E12.5 to E14.0, confirming that Osterix acts downstream of Runx2. Sox9 mRNA was expressed in Meckel's cartilage and its anlagen throughout the experimental period, but not clearly in the mandibular anlagen until E13.0. At E13.5, the condylar anlage was morphologically identified at the posterior end of the mandibular anlage, and enhanced Sox9 mRNA expression was detected here. At this stage, Runx2 and Osterix mRNA were simultaneously detected in the condylar anlage. These results indicate that the Sox9 mRNA-expressing condylar anlage is derived from Runx2/Osterix mRNA-expressing mandibular anlage, and that upregulation of Sox9 in this region acts as a trigger for subsequent condylar cartilage formation.
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