ArticleJournal of cellular and molecular medicine2009
Evaluation of blood vessel ingrowth in fibrin gel subject to type and concentration of growth factors.
Article in Journal of cellular and molecular medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 50 citations in OpenAlex.
- In Vivo Vascularization of Cell-Supplemented Spider Silk-Based Hydrogels in the Arteriovenous Loop Model.Biomimetics (Basel, Switzerland) · 2025Article
- A Versatile Skin-Derived Extracellular Matrix Hydrogel-Based Platform to Investigate the Function of a Mechanically Isolated Adipose Tissue Stromal Vascular Fraction.Biomolecules · 2024Article
- Longitudinal Monitoring of Angiogenesis in a Murine Window Chamber ModelTissue engineering. Part C, Methods · 2024Article
- Article
- Spatially-directed angiogenesis using ultrasound-controlled release of basic fibroblast growth factor from acoustically-responsive scaffolds.Acta biomaterialia · 2021Article
- In Vitro Characterization of Hypoxia Preconditioned Serum (HPS)-Fibrin Hydrogels: Basis for an Injectable Biomimetic Tissue Regeneration Therapy.Journal of functional biomaterials · 2019Article
- The pro-angiogenic role of hypoxia inducible factor stabilizer FG-4592 and its application in an in vivo tissue engineering chamber model.Scientific reports · 2019Article
- Encapsulation of Rat Bone Marrow Derived Mesenchymal Stem Cells in Alginate Dialdehyde/Gelatin Microbeads with and without Nanoscaled Bioactive Glass for In Vivo Bone Tissue Engineering.Materials (Basel, Switzerland) · 2018Article
- Heart regeneration with engineered myocardial tissue.Annual review of biomedical engineering · 2014Review
- Successful human long-term application of in situ bone tissue engineering.Journal of cellular and molecular medicine · 2014Article
- Article
- Endothelial progenitor cells are integrated in newly formed capillaries and alter adjacent fibrovascular tissue after subcutaneous implantation in a fibrin matrix.Journal of cellular and molecular medicine · 2011Article
- The reconstruction of lung alveolus-like structure in collagen-matrigel/microcapsules scaffolds in vitro.Journal of cellular and molecular medicine · 2011Article
- Changes of anabolic processes at the cellular and molecular level in chronic wounds under topical negative pressure can be revealed by transcriptome analysis.Journal of cellular and molecular medicine · 2011Article
- Role of guanylate binding protein-1 in vascular defects associated with chronic inflammatory diseases.Journal of cellular and molecular medicine · 2011Article
- Gene expression analysis of ischaemia and reperfusion in human microsurgical free muscle tissue transfer.Journal of cellular and molecular medicine · 2011Article
- Fibrin glue as a drug delivery system.Journal of controlled release : official journal of the Controlled Release Society · 2010Review
- [The development of plastic surgery: retrospective view of 80 years of "Der Chirurg" (The Surgeon)].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2009Article
- Regression and persistence: remodelling in a tissue engineered axial vascular assembly.Journal of cellular and molecular medicine · 2009Article
- Translating tissue engineering technology platforms into cancer research.Journal of cellular and molecular medicine · 2009Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Our aim was to quantitatively assess the angiogenetic effects of VEGF and bFGF immobilized in a fibrin-based drug delivery system in a suitable subcutaneous rat model. After evaluation of a suitable implantation technique (6 rats), four teflon isolation chambers containing fibrin gel matrices were implanted subcutaneously in an upside-down fashion on the back of 30 Lewis rats. The matrices consisted of 500 microl fibrin gel with two different fibrinogen concentrations (10 mg/ml or 40 mg/ml fibrinogen) and 2 I.U./ml thrombin and contained VEGF and bFGF in five different concentrations (0 to 250 ng/ml each). At 3, 7 and 14 days after implantation, matrices were explanted and subjected to histological and morphometrical analysis. At 1 week, the volume of the fibrin clots was significantly smaller in the 100 and 250 ng/ml VEGF and bFGF groups in comparison to lower concentrated growth factors. At 1 and 2 weeks, the use of growth factors in low concentrations (25 ng/ml VEGF and bFGF) significantly increased the amount of fibrovascular tissue, average fraction of blood vessels and number of blood vessels at the matrix-host interface in comparison to growth factor-free controls. Higher concentrations were neither associated with further increase of tissue formation nor with increased sprouting of blood vessels in this model. This study demonstrates that fibrin gel-immobilized angioinductive growth factors efficiently stimulate generation of fibrovascular tissue and sprouting of blood vessels in a newly developed subcutaneous upside-down isolation chamber model with an optimum between 25 and 100 ng/ml.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.