ReviewJournal of cellular and molecular medicine2009
Acute heart inflammation: ultrastructural and functional aspects of macrophages elicited by Trypanosoma cruzi infection.
Review in Journal of cellular and molecular medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- Biological and Molecular Characterization of FiveTropical medicine and infectious disease · 2025Article
- Towards a map of the immune system manipulation network byFrontiers in cellular and infection microbiology · 2025Review
- Immunopathogenesis inFrontiers in immunology · 2023Review
- Tissue-resident M2 macrophages directly contact primary sensory neurons in the sensory ganglia after nerve injury.Journal of neuroinflammation · 2021Article
- Pyridinecarboxylic Acid Derivative Stimulates Pro-Angiogenic Mediators by PI3K/AKT/mTOR and Inhibits Reactive Nitrogen and Oxygen Species and NF-κB Activation Through a PPARγ-Dependent Pathway inFrontiers in immunology · 2019Article
- Treatment with a New Peroxisome Proliferator-Activated Receptor Gamma Agonist, Pyridinecarboxylic Acid Derivative, Increases Angiogenesis and Reduces Inflammatory Mediators in the Heart ofFrontiers in immunology · 2017Article
- New Insights into the Immunobiology of Mononuclear Phagocytic Cells and Their Relevance to the Pathogenesis of Cardiovascular Diseases.Frontiers in immunology · 2017Review
- Lipid Body Organelles within the Parasite Trypanosoma cruzi: A Role for Intracellular Arachidonic Acid Metabolism.PloS one · 2016Article
- Host Lipid Bodies as Platforms for Intracellular Survival of Protozoan Parasites.Frontiers in immunology · 2016Review
- 20S-dihydroprotopanaxatriol modulates functional activation of monocytes and macrophages.Journal of ginseng research · 2013Article
- The internal architecture of leukocyte lipid body organelles captured by three-dimensional electron microscopy tomography.PloS one · 2013Article
- Bone marrow-derived cell therapy in chagasic cardiac disease: a review of pre-clinical and clinical results.Cardiovascular diagnosis and therapy · 2012Review
- Curcumin treatment provides protection against Trypanosoma cruzi infection.Parasitology research · 2012Article
- Macrophage diversity in cardiac inflammation: a review.Immunobiology · 2012Review
- Lipid bodies: inflammatory organelles implicated in host-Trypanosoma cruzi interplay during innate immune responses.Mediators of inflammation · 2012Article
- Lipid bodies in inflammatory cells: structure, function, and current imaging techniques.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2011Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The heart is the main target organ of the parasite Trypanosoma cruzi, the causal agent of Chagas' disease, a significant public health issue and still a major cause of morbidity and mortality in Latin America. During the acute disease, tissue damage in the heart is related to the intense myocardium parasitism. To control parasite multiplication, cells of the monocytic lineage are highly mobilized. In response to inflammatory and immune stimulation, an intense migration and extravasation of monocytes occurs from the bloodstream into heart. Monocyte differentiation leads to the formation of tissue phagocytosing macrophages, which are strongly activated and direct host defence. Newly elicited monocyte-derived macrophages both undergo profound physiological changes and display morphological heterogeneity that greatly differs from originally non-inflammatory macrophages, and underlie their functional activities as potent inflammatory cells. Thus, activated macrophages play a critical role in the outcome of parasite infection. This review covers functional and ultrastructural aspects of heart inflammatory macrophages triggered by the acute Chagas' disease, including recent discoveries on morphologically distinct, inflammation-related organelles, termed lipid bodies, which are actively formed in vivo within macrophages in response to T. cruzi infection. These findings are defining a broader role for lipid bodies as key markers of macrophage activation during innate immune responses to infectious diseases and attractive targets for novel anti-inflammatory therapies. Modulation of macrophage activation may be central in providing therapeutic benefits for Chagas' disease control.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.