ArticleJournal of clinical laboratory analysis2008
RNA from Borna disease virus in patients with schizophrenia, schizoaffective patients, and in their biological relatives.
Article in Journal of clinical laboratory analysis, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 32 citations in OpenAlex.
- Unravelling the Viral Hypothesis of Schizophrenia: A Comprehensive Review of Mechanisms and Evidence.International journal of molecular sciences · 2025Review
- Activation of ERK/CREB/BDNF pathway involved in abnormal behavior of neonatally Borna virus-infected rats.Neuropsychiatric disease and treatment · 2018Article
- Viral component of the human genome.Molecular biology · 2017Review
- Detection of Borna Disease Virus (BDV) in Patients with First Episode of Schizophrenia.Iranian journal of psychiatry · 2016Article
- Borna disease virus (BDV) infection in psychiatric patients and healthy controls in Iran.Virology journal · 2014Article
- Human but Not Laboratory Borna Disease Virus Inhibits Proliferation and Induces Apoptosis in Human Oligodendrocytes In Vitro.PloS one · 2013Article
- Infectious Agents are Associated with Psychiatric Diseases.Mental illness · 2012Article
- Association of increased prenatal estrogen with risk factors for schizophrenia.Schizophrenia bulletin · 2011Review
- The mind-body-microbial continuum.Dialogues in clinical neuroscience · 2011Article
- Borna disease virus (BDV) circulating immunocomplex positivity in addicted patients in the Czech Republic: a prospective cohort analysis.BMC psychiatry · 2010Article
- Failure to detect borna disease virus antibody and RNA from peripheral blood mononuclear cells of psychiatric patients.Psychiatry investigation · 2009Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Numerous interactions of the immune system with the central nervous system have been described recently. Mood and psychotic disorders, such as severe depression and schizophrenia, are both heterogeneous disorders regarding clinical symptomatology, the acuity of symptoms, the clinical course, the treatment response, and probably also the etiology. Detection of p24 RNA from Borna disease virus (BDV) by the reverse transcriptase polymerase chain reaction in patients with schizophrenia, schizoaffective disorder, and in their biological relatives was evaluated. The subjects were 27 schizophrenic and schizoaffective patients, 27 healthy controls, 20 relatives without psychiatric disease, and 24 relatives with mood disorder, who attended the Psychiatric Ambulatory of Londrina State University, Paraná, Brazil. The subjects were interviewed by structured diagnostic criteria categorized according to the Diagnostic and Statistical Manual of Mental Disorders-IV, axis I, (SCID-IV). The mean duration of illness in schizophrenic and schizoaffective patients was 15.341+/-1.494 years and the median age at onset was 22.4+/-7.371 years. There were no significant differences in gender (P=0.297), age (P=0.99), albumin (P=0.26), and body mass index (kg/m(2)) (p=0.28), among patients, controls, and relatives. Patients and biological relatives had significantly higher positive p24 RNA BDV detection than controls (P=0.04); however, the clinical significance of BDV remains to be clarified.
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