ArticleMolecular biology reports2009
An alternative method for genotyping of the ACE I/D polymorphism.
Article in Molecular biology reports, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Lack of replication in polymorphisms reported to be associated with atrial fibrillation.Heart rhythm · 2011Pooled it
- Length Polymorphisms in the Angiotensin I-Converting Enzyme Gene and the Serotonin-Transporter-Linked Polymorphic Region Constitute a Risk Haplotype for Depression in Patients with Coronary Artery Disease.Biochemical genetics · 2020Trial
- Angiotensin-Converting Enzyme 1 (ACE1) gene polymorphisms in pediatric patients with COVID-19: impact on disease severity and outcomes.BMC medical genomics · 2026Article
- Exploring the Relationship between ACE Gene Variants and Systemic Lupus Erythematosus Susceptibility in the Hainan Population through Genetic Association Analysis.Current rheumatology reviews · 2025Article
- ACE I/D gene polymorphisms and polycystic ovary syndrome manifestations.Journal of diabetes and metabolic disorders · 2024Article
- Elevated ACE Levels Indicate Diabetic Nephropathy Progression or Companied Retina Impaired.Frontiers in clinical diabetes and healthcare · 2022Article
- Gene Polymorphisms of the Renin-Angiotensin System and Bleeding Complications of Warfarin: Genetic-Based Machine Learning Models.Pharmaceuticals (Basel, Switzerland) · 2021Article
- Alu retrotransposons and COVID-19 susceptibility and morbidity.Human genomics · 2021Review
- ACE Gene Variants Rise the Risk of Severe COVID-19 in Patients With Hypertension, Dyslipidemia or Diabetes: A Spanish Pilot Study.Frontiers in endocrinology · 2021Article
- A Potential Endurance Algorithm Prediction in the Field of Sports Performance.Frontiers in genetics · 2020Article
- Childhood adiposity, adult adiposity, and the ACE gene insertion/deletion polymorphism: evidence of gene-environment interaction effects on adult blood pressure and hypertension status in adulthood.Journal of hypertension · 2018Article
- No association between ACTN3 R577X and ACE I/D polymorphisms and endurance running times in 698 Caucasian athletes.BMC genomics · 2018Article
- Proposed guidelines to evaluate scientific validity and evidence for genotype-based dietary advice.Genes & nutrition · 2017Review
- Article
- Polymorphism of angiotensin-converting enzyme (rs4340) and diabetic nephropathy in Caucasians with type 2 diabetes mellitus.Balkan journal of medical genetics : BJMG · 2016Article
- Study of the association between the donors and recipients angiotensin-converting enzyme insertion/deletion gene polymorphism and the acute renal allograft rejection.Journal of nephropathology · 2015Article
- Association between the ACE gene I/D polymorphism and osteoporosis in a Turkish population.Zeitschrift fur Rheumatologie · 2015Article
- DD genotype of ACE gene I/D polymorphism is associated with Behcet disease in a Turkish population.Molecular biology reports · 2013Article
- Association of the APOE, MTHFR and ACE Genes Polymorphisms and Stroke in Zambian Patients.Neurology international · 2013Article
- Significant association between insertion/deletion polymorphism of the angiotensin-convertig enzyme gene and ankylosing spondylitis.Molecular vision · 2012Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mistyping of the angiotensin I-converting enzyme insertion/deletion (ACE I/D) has been well documented, and new methods have been suggested here to improve the genotyping efficiency. Buccal cell samples were collected from 157 young Caucasians, and genotyped using previously known and newly developed PCR amplification genotyping techniques, as well as PCR-RFLP tests for three single nucleotide polymorphisms (rs4327, rs4341 and rs4343). Inconsistent genotyping results were found when using only the PCR amplification genotyping techniques across repeated attempts (8% to 45%), however, individual SNP genotyping was highly consistent (100%). Two SNPs (rs4341 and rs4343) were in complete LD and SNP rs4327 was in high LD with the ACE I/D. The ACE I/D was in HW equilibrium in the portion of the population with consistent genotyping results, whereas the three SNPs were not in HW equilibrium. The mistyping of ACE I/D by only PCR amplification can be improved using alternative methods.
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