Evidence map›Paper›PMID 18622392›Full record

ArticleNature structural & molecular biology2008

Fission yeast SWI/SNF and RSC complexes show compositional and functional differences from budding yeast.

Brendon J Monahan, Judit Villén, Samuel Marguerat, Jürg Bähler, Steven P Gygi, Fred Winston

Open access · greenAbstract read
In one paragraph

Article in Nature structural & molecular biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 125 citations in OpenAlex.

  1. Article
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  7. Article
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  10. MoSnf5 Regulates Fungal Virulence, Growth, and Conidiation inJournal of fungi (Basel, Switzerland) · 2022
    Article
  11. Article
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  14. Review
  15. Review
  16. Article
  17. On and Off: Epigenetic Regulation ofPathogens (Basel, Switzerland) · 2021
    Review
  18. The Active Mechanism of Nucleosome Depletion by Poly(dA:dT) Tracts In Vivo.International journal of molecular sciences · 2021
    Review
  19. Article
  20. Review

11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Brendon J MonahanDepartment of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.
Judit Villén
Samuel Marguerat
Jürg Bähler
Steven P Gygi
Fred Winston
Harvard University · USWellcome Sanger Institute · GB

Funding

Factors Controlling Transcription and Chromatin in YeastR37GM032967 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WINSTON, FRED M. · 2004 to 2013
$4.9M
INSERTION MUTATION SUPPRESSORS IN YEASTR01GM032967 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WINSTON, FRED M. · 1985 to 2017
$3.6M
New Technologies for Quantitative Phosphorylation AnalysisR01HG003456 · NHGRI · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI GYGI, STEVEN P · 2005 to 2011
$2.7M
Cancer Research UK A6517Cancer Research UK C9546/A6517NHGRI NIH HHS HG3456NHGRI NIH HHS R01 HG003456NIGMS NIH HHS GM32967NIGMS NIH HHS R01 GM032967NIGMS NIH HHS R37 GM032967Wellcome Trust 077118
6 · The paper itself

Abstract

SWI/SNF chromatin-remodeling complexes have crucial roles in transcription and other chromatin-related processes. The analysis of the two members of this class in Saccharomyces cerevisiae, SWI/SNF and RSC, has heavily contributed to our understanding of these complexes. To understand the in vivo functions of SWI/SNF and RSC in an evolutionarily distant organism, we have characterized these complexes in Schizosaccharomyces pombe. Although core components are conserved between the two yeasts, the compositions of S. pombe SWI/SNF and RSC differ from their S. cerevisiae counterparts and in some ways are more similar to metazoan complexes. Furthermore, several of the conserved proteins, including actin-like proteins, are markedly different between the two yeasts with respect to their requirement for viability. Finally, phenotypic and microarray analyses identified widespread requirements for SWI/SNF and RSC on transcription including strong evidence that SWI/SNF directly represses iron-transport genes.

Indexed as

Gene Expression Regulation, FungalActinsChromatinChromosomal Proteins, Non-HistoneDNA-Binding ProteinsGene DeletionHumansNuclear ProteinsPhenotypeSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSchizosaccharomycesSchizosaccharomyces pombe ProteinsSpecies SpecificityTranscription FactorsTranscription, GeneticActinsChromatinChromosomal Proteins, Non-HistoneDNA-Binding ProteinsNuclear ProteinsSaccharomyces cerevisiae ProteinsSchizosaccharomyces pombe Proteinssnf22 protein, S pombeSNF5 protein, S cerevisiaeTranscription Factors

Identifiers

PMID18622392
PMCPMC2559950
OpenAlexW2068750645

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.