ArticleThe Laryngoscope2008
A genomewide screen for chronic rhinosinusitis genes identifies a locus on chromosome 7q.
Article in The Laryngoscope, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 33 citations in OpenAlex.
- Genome-wide Association Study of Susceptibility Loci for Self-Reported Atopic Dermatitis and Allergic Rhinitis in the Korean Population.Annals of dermatology · 2024Article
- Chronic Rhinosinusitis-Microbiological Etiology, Potential Genetic Markers, and Diagnosis.International journal of molecular sciences · 2024Review
- An Overview of the Application of Systems Biology in an Understanding of Chronic Rhinosinusitis (CRS) Development.Journal of personalized medicine · 2020Review
- Acquired cystic fibrosis transmembrane conductance regulator dysfunction.World journal of otorhinolaryngology - head and neck surgery · 2018Review
- Immunopathogenesis of Chronic Rhinosinusitis and Nasal Polyposis.Annual review of pathology · 2017Review
- Article
- Channel Gating Regulation by the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) First Cytosolic Loop.The Journal of biological chemistry · 2016Article
- Risk factors for chronic rhinosinusitis.Current opinion in allergy and clinical immunology · 2015Review
- Genetics of chronic rhinosinusitis: state of the field and directions forward.The Journal of allergy and clinical immunology · 2013Review
- Chronic rhinosinusitis as a multifactorial inflammatory disorder.Current infectious disease reports · 2011Article
- Rhinosinusitis and comorbidities.Current allergy and asthma reports · 2010Review
- Article
- Rhinosinusitis: evidence and experience: October 18 and 19, 2013 - São Paulo.Brazilian journal of otorhinolaryngologyArticle
- Chronic Rhinosinusitis without Nasal Polyps.The journal of allergy and clinical immunology. In practiceReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objective/hypothesisChronic rhinosinusitis (CRS) is an important public health problem with substantial impact on patient quality of life and health care costs. We hypothesized that genetic variation may be one factor that affects this disease. STUDY
designIdentification of genetic variation underlying susceptibility to CRS using linkage analysis in a founder population.
methodsWe studied a religious isolate that practices a communal lifestyle and shares common environmental exposures. Using physical examination, medical interviews, and a review of medical records, we identified eight individuals with CRS of 291 screened. These eight individuals were related to each other in a single 60 member, nine generation pedigree. A genome-wide screen for loci influencing susceptibility to CRS using 1123 genome-wide markers was conducted.
resultsThe largest linkage peak (P = .0023; 127.15 cM, equivalent to limit of detection = 2.01) was on chromosome 7q31.1-7q32.1, 7q31 (127.15 cM; 1-limit of detection support region: 115-135 cM) and included the CFTR locus. Genotyping of 38 mutations in the CFTR gene did not reveal variation accounting for this linkage signal.
conclusionsUnderstanding the genes involved in CRS may lead to improvements in its diagnosis and treatment. Our results represent the first genome-wide screen for CRS and suggest that a locus on 7q31.1-7q32.1 influences disease susceptibility. This may be the CFTR gene or another nearby locus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.