ArticleGenetics2008
Dissection of the genetic architecture of body weight in chicken reveals the impact of epistasis on domestication traits.
Article in Genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Article
- MIDESP: Mutual Information-Based Detection of Epistatic SNP Pairs for Qualitative and Quantitative Phenotypes.Biology · 2021Article
- A genome-wide association analysis for body weight at 35 days measured on 137,343 broiler chickens.Genetics, selection, evolution : GSE · 2021Article
- Quantitative trait loci for growth-related traits in Japanese quail (Coturnix japonica) using restriction-site associated DNA sequencing.Molecular genetics and genomics : MGG · 2021Article
- The Impact of Non-additive Effects on the Genetic Correlation Between Populations.G3 (Bethesda, Md.) · 2020Article
- Maladaptation in feral and domesticated animals.Evolutionary applications · 2019Review
- Mapping of Quantitative Trait Loci for Growth and Carcass-Related Traits in Chickens Using a Restriction-Site Associated DNA Sequencing Method.The journal of poultry science · 2019Article
- Genetical genomics of growth in a chicken model.BMC genomics · 2018Article
- A molecular genome scan to identify DNA segments associated with live weight in Japanese quail.Molecular biology reports · 2016Article
- Genome-wide association studies of immune, disease and production traits in indigenous chicken ecotypes.Genetics, selection, evolution : GSE · 2016Article
- Identification of quantitative trait loci for body temperature, body weight, breast yield, and digestibility in an advanced intercross line of chickens under heat stress.Genetics, selection, evolution : GSE · 2015Article
- Estimation of Additive, Dominance, and Imprinting Genetic Variance Using Genomic Data.G3 (Bethesda, Md.) · 2015Article
- Estimating directional epistasis.Frontiers in genetics · 2014Article
- MAPfastR: quantitative trait loci mapping in outbred line crosses.G3 (Bethesda, Md.) · 2013Article
- Genome-wide interval mapping using SNPs identifies new QTL for growth, body composition and several physiological variables in an F2 intercross between fat and lean chicken lines.Genetics, selection, evolution : GSE · 2013Article
- Article
- Genetic dissection of growth traits in a Chinese indigenous × commercial broiler chicken cross.BMC genomics · 2013Article
- Effect of regulatory architecture on broad versus narrow sense heritability.PLoS computational biology · 2013Article
- Current applications of models of genetic effects with interactions across the genome.Current genomics · 2012Article
- Genome-wide association study identified a narrow chromosome 1 region associated with chicken growth traits.PloS one · 2012Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this contribution, we study the genetic mechanisms leading to differences in the observed growth patterns of domesticated White Leghorn chickens and their wild ancestor the red jungle fowl. An epistatic QTL analysis for several body-weight measures from hatch to adulthood confirms earlier findings that polymorphisms at >15 loci contribute to body-weight determination in an F(2) intercross between these populations and that many loci are involved in complex genetic interactions. Here, we use a new genetic model to decompose the genetic effects of this multilocus epistatic genetic network. The results show how the functional modeling of genetic effects provides new insights into how genetic interactions in a large set of loci jointly contribute to phenotypic expression. By exploring the functional effects of QTL alleles, we show that some alleles can display temporal shifts in the expression of genetic effects due to their dependencies on the genetic background. Our results demonstrate that the effects of many genes are dependent on genetic interactions with other loci and how their involvement in the domestication process relies on these interactions.
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