ArticleMolecular & cellular proteomics : MCP2008
Identification of diagnostic biomarkers for infection in premature neonates.
Article in Molecular & cellular proteomics : MCP, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 62 citations in OpenAlex.
- Assessment of Serum Interleukins 18 and 22 in Predicting Neonatal Sepsis and Mortality: A Case-Control Study.Clinical medicine insights. Pediatrics · 2026Article
- The Role of IL-6 in the Diagnosis of Neonatal Sepsis and Its Influence on Maternal Mental Health.Cureus · 2025Article
- Study of some biological markers in cord blood of preterm and term infants and their association with neonatal sepsis.Pediatric endocrinology, diabetes, and metabolism · 2025Article
- Epigenetic scores derived in saliva are associated with gestational age at birth.Clinical epigenetics · 2024Article
- Investigation of salivary C-reactive protein and interleukin-18 for the diagnosis of neonatal sepsis.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2021Article
- Targeting IL-17A attenuates neonatal sepsis mortality induced by IL-18.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Biological functions of thyroid hormone in placenta.International journal of molecular sciences · 2015Review
- Time for a neonatal-specific consensus definition for sepsis.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2014Review
- Article
- Clinical value of plasma soluble urokinase-type plasminogen activator receptor levels in term neonates with infection or sepsis: a prospective study.Mediators of inflammation · 2014Article
- An integrated clinico-metabolomic model improves prediction of death in sepsis.Science translational medicine · 2013Article
- Cytokine profiles of preterm neonates with fungal and bacterial sepsis.Pediatric research · 2012Article
- Cytokine screening identifies NICU patients with Gram-negative bacteremia.Pediatric research · 2012Article
- Immunoregulatory protein profiles of necrotizing enterocolitis versus spontaneous intestinal perforation in preterm infants.PloS one · 2012Article
- The role of IL-6 for predicting neonatal sepsis: a systematic review and meta-analysis.Iranian journal of pediatrics · 2011Article
- Emerging biomarkers for the diagnosis of severe neonatal infections applicable to low resource settings.Journal of global health · 2011Article
- Article
- Identification of candidate serum biomarkers for severe septic shock-associated kidney injury via microarray.Critical care (London, England) · 2011Article
- Biomarkers for pediatric sepsis and septic shock.Expert review of anti-infective therapy · 2011Review
- Inter-alpha inhibitor protein administration improves survival from neonatal sepsis in mice.Pediatric research · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 5 institutions in 2 countries.
Funding
Abstract
Infection is a leading cause of neonatal morbidity and mortality worldwide. Premature neonates are particularly susceptible to infection because of physiologic immaturity, comorbidity, and extraneous medical interventions. Additionally premature infants are at higher risk of progression to sepsis or severe sepsis, adverse outcomes, and antimicrobial toxicity. Currently initial diagnosis is based upon clinical suspicion accompanied by nonspecific clinical signs and is confirmed upon positive microbiologic culture results several days after institution of empiric therapy. There exists a significant need for rapid, objective, in vitro tests for diagnosis of infection in neonates who are experiencing clinical instability. We used immunoassays multiplexed on microarrays to identify differentially expressed serum proteins in clinically infected and non-infected neonates. Immunoassay arrays were effective for measurement of more than 100 cytokines in small volumes of serum available from neonates. Our analyses revealed significant alterations in levels of eight serum proteins in infected neonates that are associated with inflammation, coagulation, and fibrinolysis. Specifically P- and E-selectins, interleukin 2 soluble receptor alpha, interleukin 18, neutrophil elastase, urokinase plasminogen activator and its cognate receptor, and C-reactive protein were observed at statistically significant increased levels. Multivariate classifiers based on combinations of serum analytes exhibited better diagnostic specificity and sensitivity than single analytes. Multiplexed immunoassays of serum cytokines may have clinical utility as an adjunct for rapid diagnosis of infection and differentiation of etiologic agent in neonates with clinical decompensation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.