ArticleBiophysical journal2008
Influence of nonuniform geometry on nanoindentation of viral capsids.
Article in Biophysical journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 72 citations in OpenAlex.
- Protocol for AFM Nanoindentation of Viruses and Protein Cages.Methods in molecular biology (Clifton, N.J.) · 2027Article
- Bio-Inspired Sutures: Using Finite Element Analysis to Parameterize the Mechanical Response of Dovetail Sutures in Simulated Bending of a Curved Structure.Biomimetics (Basel, Switzerland) · 2022Article
- Contact-Based Analysis of Aggregation of Intrinsically Disordered Proteins.Methods in molecular biology (Clifton, N.J.) · 2022Review
- Bridging between material properties of proteins and the underlying molecular interactions.PloS one · 2021Article
- Dynamic AFM detection of the oxidation-induced changes in size, stiffness, and stickiness of low-density lipoprotein.Journal of nanobiotechnology · 2020Article
- Minimal Cylinder Analysis Reveals the Mechanical Properties of Oncogenic Nucleosomes.Biophysical journal · 2020Article
- Optimal Coarse-Grained Site Selection in Elastic Network Models of Biomolecules.Journal of chemical theory and computation · 2019Article
- Article
- Viral nanomechanics with a virtual atomic force microscope.Journal of physics. Condensed matter : an Institute of Physics journal · 2018Article
- Post-buckling of a pressured biopolymer spherical shell with the mode interaction.Proceedings. Mathematical, physical, and engineering sciences · 2018Article
- Fluctuating Nonlinear Spring Model of Mechanical Deformation of Biological Particles.PLoS computational biology · 2016Article
- Swelling and softening of the cowpea chlorotic mottle virus in response to pH shifts.Biophysical journal · 2015Article
- Imaging and force measurement of LDL and HDL by AFM in air and liquid.FEBS open bio · 2015Article
- Recent Developments in Molecular Simulation Approaches to Study Spherical Virus Capsids.Molecular simulation · 2014Article
- Structural transitions and energy landscape for Cowpea Chlorotic Mottle Virus capsid mechanics from nanomanipulation in vitro and in silico.Biophysical journal · 2013Article
- Integrin and defensin modulate the mechanical properties of adenovirus.Journal of virology · 2013Article
- Mechanical and assembly units of viral capsids identified via quasi-rigid domain decomposition.PLoS computational biology · 2013Article
- Nanoindentation of 35 virus capsids in a molecular model: relating mechanical properties to structure.PloS one · 2013Article
- Viral capsid equilibrium dynamics reveals nonuniform elastic properties.Biophysical journal · 2011Article
- Conformational dynamics data bank: a database for conformational dynamics of proteins and supramolecular protein assemblies.Nucleic acids research · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A series of recent nanoindentation experiments on the protein shells (capsids) of viruses has established atomic force microscopy (AFM) as a useful framework for probing the mechanics of large protein assemblies. Specifically these experiments provide an opportunity to study the coupling of the global assembly response to local conformational changes. AFM experiments on cowpea chlorotic mottle virus, known to undergo a pH-controlled swelling conformational change, have revealed a pH-dependent mechanical response. Previous theoretical studies have shown that homogeneous changes in shell geometry can play a significant role in the mechanical response. This article develops a method for accurately capturing the heterogeneous geometry of a viral capsid and explores its effect on mechanical response with a nonlinear continuum elasticity model. Models of both native and swollen cowpea chlorotic mottle virus capsids are generated from x-ray crystal structures, and are used in finite element simulations of AFM indentation along two-, three-, and fivefold icosahedral symmetry orientations. The force response of the swollen capsid model is observed to be softer by roughly a factor of two, significantly more nonlinear, and more orientation-dependent than that of a native capsid with equivalent elastic moduli, demonstrating that capsid geometric heterogeneity can have significant effects on the global structural response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.