ArticleThe Journal of biological chemistry2008
Acetylation of PML is involved in histone deacetylase inhibitor-mediated apoptosis.
Article in The Journal of biological chemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 42 citations in OpenAlex.
- PML::RARA and GATA2 proteins interact via DNA templates to induce aberrant self-renewal in mouse and human hematopoietic cells.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- USP22 regulates APL differentiation via PML-RARα stabilization and IFN repression.Cell death discovery · 2024Article
- The PML hub: An emerging actor of leukemia therapies.The Journal of experimental medicine · 2023Article
- A PML/RARα direct target atlas redefines transcriptional deregulation in acute promyelocytic leukemia.Blood · 2021Article
- PML nuclear body biogenesis and oligomerization-driven leukemogenesis.Blood science (Baltimore, Md.) · 2020Review
- PML: Regulation and multifaceted function beyond tumor suppression.Cell & bioscience · 2018Review
- Arsenic trioxide disrupts glioma stem cells via promoting PML degradation to inhibit tumor growth.Oncotarget · 2015Article
- The function, regulation and therapeutic implications of the tumor suppressor protein, PML.Cell & bioscience · 2015Review
- Deacetylation of the tumor suppressor protein PML regulates hydrogen peroxide-induced cell death.Cell death & disease · 2014Article
- PML-mediated signaling and its role in cancer stem cells.Oncogene · 2014Review
- PML nuclear bodies: assembly and oxidative stress-sensitive sumoylation.Nucleus (Austin, Tex.) · 2014Review
- New Strategies to Direct Therapeutic Targeting of PML to Treat Cancers.Frontiers in oncology · 2013Article
- PML Degradation: Multiple Ways to Eliminate PML.Frontiers in oncology · 2013Article
- PML: Not all about Tumor Suppression.Frontiers in oncology · 2013Article
- MageA2 restrains cellular senescence by targeting the function of PMLIV/p53 axis at the PML-NBs.Cell death and differentiation · 2012Article
- PML regulates PER2 nuclear localization and circadian function.The EMBO journal · 2012Article
- Post-translational modifications of PML: consequences and implications.Frontiers in oncology · 2012Article
- Regulation of the tumor suppressor PML by sequential post-translational modifications.Frontiers in oncology · 2012Article
- SUMO modification of Stra13 is required for repression of cyclin D1 expression and cellular growth arrest.PloS one · 2012Article
- The nuclear bodies inside out: PML conquers the cytoplasm.Current opinion in cell biology · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
PML is a potent tumor suppressor and proapoptotic factor and is functionally regulated by post-translational modifications such as phosphorylation, sumoylation, and ubiquitination. Histone deacetylase (HDAC) inhibitors are a promising class of targeted anticancer agents and induce apoptosis in cancer cells by largely unknown mechanisms. We report here a novel post-transcriptional modification, acetylation, of PML. PML exists as an acetylated protein in HeLa cells, and its acetylation is enhanced by coexpression of p300 or treatment with a HDAC inhibitor, trichostatin A. Increased PML acetylation is associated with increased sumoylation of PML in vitro and in vivo. PML is involved in trichostatin A-induced apoptosis and PML with an acetylation-defective mutation shows an inability to mediate apoptosis, suggesting the importance of PML acetylation. Our work provides new insights into PML regulation by post-translational modification and new information about the therapeutic mechanism of HDAC inhibitors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.