ArticleProceedings of the National Academy of Sciences of the United States of America2008
The RPG gene of Medicago truncatula controls Rhizobium-directed polar growth during infection.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
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Who cites it
61 citing papers in PubMed.
- A recently evolved Nodulin recruited by NIN for root hair rhizobial infection in Medicago truncatula.The New phytologist · 2026Article
- Nissolia brasiliensis as a nonnodulating model legume.Plant physiology · 2026Article
- Chromosome-Level Genome and Organ-Specific Transcriptome of Alnus glutinosa Uncover Lineage-Specific Innovations in Root Nodule Symbiosis.Plant, cell & environment · 2026Article
- Cyclophilin A-mediated cis/trans isomerization modulates RIN4 to control intracellular rhizobial infection in legumes.The New phytologist · 2026Article
- The phosphate-solubilizing capacity of Rhizobium tropici LNP6 and its growth-promoting effects on Ormosia hosiei seedlings.BMC plant biology · 2026Article
- Multi-omics profiling of Nanhaia speciosa and Nanhaia fordii: insights into lectin dynamics, nodulation, and triterpenoid saponin biosynthesis.BMC biology · 2025Article
- Enacting partner specificity in legume-rhizobia symbioses.aBIOTECH · 2025Review
- Symbiotic nitrogen fixation: a launchpad for investigating old and new challenges.Journal of experimental botany · 2025Article
- Cellular basis of legume-rhizobium symbiosis.Plant communications · 2024Review
- Conserved cis-elements enable NODULES WITH ACTIVATED DEFENSE1 regulation by NODULE INCEPTION during nodulation.The Plant cell · 2024Article
- Differential symbiotic compatibilities between rhizobium strains and cultivated and wild soybeans revealed by anatomical and transcriptome analyses.Frontiers in plant science · 2024Article
- Signaling in Legume-Rhizobia Symbiosis.International journal of molecular sciences · 2023Review
- Single-nucleus transcriptomes reveal spatiotemporal symbiotic perception and early response in Medicago.Nature plants · 2023Article
- Comparative phylotranscriptomics reveals ancestral and derived root nodule symbiosis programmes.Nature plants · 2023Article
- Integrated single-nucleus and spatial transcriptomics captures transitional states in soybean nodule maturation.Nature plants · 2023Article
- Identification and Characterization of Common Bean (Plants (Basel, Switzerland) · 2023Article
- Dancing to a different tune, can we switch from chemical to biological nitrogen fixation for sustainable food security?PLoS biology · 2023Article
- Article
- RPG interacts with E3-ligase CERBERUS to mediate rhizobial infection in Lotus japonicus.PLoS genetics · 2023Article
- NIN-at the heart of NItrogen-fixing Nodule symbiosis.Frontiers in plant science · 2023Review
1 more citing papers are in PubMed but not listed here.
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6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rhizobia can infect roots of host legume plants and induce new organs called nodules, in which they fix atmospheric nitrogen. Infection generally starts with root hair curling, then proceeds inside newly formed, intracellular tubular structures called infection threads. A successful symbiotic interaction relies on infection threads advancing rapidly at their tips by polar growth through successive cell layers of the root toward developing nodule primordia. To identify a plant component that controls this tip growth process, we characterized a symbiotic mutant of Medicago truncatula, called rpg for rhizobium-directed polar growth. In this mutant, nitrogen-fixing nodules were rarely formed due to abnormally thick and slowly progressing infection threads. Root hair curling was also abnormal, indicating that the RPG gene fulfils an essential function in the process whereby rhizobia manage to dominate the process of induced tip growth for root hair infection. Map-based cloning of RPG revealed a member of a previously unknown plant-specific gene family encoding putative long coiled-coil proteins we have called RRPs (RPG-related proteins) and characterized by an "RRP domain" specific to this family. RPG expression was strongly associated with rhizobial infection, and the RPG protein showed a nuclear localization, indicating that this symbiotic gene constitutes an important component of symbiotic signaling.
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