ArticleProceedings of the National Academy of Sciences of the United States of America1991
Correlation between retinoblastoma gene expression and differentiation in human testicular tumors.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 114 citations in OpenAlex.
- Meta-Analysis of Gene Expressions in Testicular Germ Cell Tumor Histologies.International journal of molecular sciences · 2020Pooled it
- Pure testicular choriocarcinoma, a rare and highly malignant subtype with challenging treatment: A case report and review of the literature.Molecular and clinical oncology · 2024Article
- Epigenetic Regulation of Driver Genes in Testicular Tumorigenesis.International journal of molecular sciences · 2023Review
- Overcoming Chemotherapy Resistance in Germ Cell Tumors.Biomedicines · 2022Review
- CDK4/6 inhibition presents as a therapeutic option for paediatric and adult germ cell tumours and induces cell cycle arrest and apoptosis via canonical and non-canonical mechanisms.British journal of cancer · 2020Article
- Article
- Review
- Platinum-refractory germ cell tumors: an update on current treatment options and developments.World journal of urology · 2017Review
- Retinoblastoma protein (RB1) controls fate determination in stem cells and progenitors of the mouse male germline.Biology of reproduction · 2013Article
- Downregulation of microRNA-383 is associated with male infertility and promotes testicular embryonal carcinoma cell proliferation by targeting IRF1.Cell death & disease · 2010Article
- Loss of heterozygosity of CDKN2A (p16INK4a) and RB1 tumor suppressor genes in testicular germ cell tumors.Radiology and oncology · 2010Article
- Testicular Germ Cell Tumors: A Paradigm for the Successful Treatment of Solid Tumor Stem Cells.Current cancer therapy reviews · 2006Article
- Induction of apoptosis by flavopiridol unrelated to cell cycle arrest in germ cell tumour derived cell lines.Investigational new drugs · 2005Article
- New insights into the pathology and molecular biology of human germ cell tumors.World journal of urology · 2004Review
- Expression of the normal epithelial cell-specific 1 (NES1; KLK10) candidate tumour suppressor gene in normal and malignant testicular tissue.British journal of cancer · 2001Article
- Lack of p19INK4d in human testicular germ-cell tumours contrasts with high expression during normal spermatogenesis.Oncogene · 2000Article
- Expression of G1-->S transition regulatory molecules in human urothelial cancer.Japanese journal of cancer research : Gann · 1998Article
- Molecular cytogenetic analysis of adult testicular germ cell tumours and identification of regions of consensus copy number change.British journal of cancer · 1998Article
- Detection of human papillomavirus DNA and oncoprotein overexpression are associated with distinct morphological patterns of tonsillar squamous cell carcinoma.The American journal of pathology · 1998Article
- Frequent p16INK4 (MTS1) gene inactivation in testicular germ cell tumors.The American journal of pathology · 1997Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Inactivation of the retinoblastoma gene (RB gene) is associated with the development of several human malignancies including retinoblastomas, some osteo- and soft tissue sarcomas, small cell lung cancer, and possibly breast and bladder cancers. To our knowledge, this gene has not been evaluated in human germ-cell malignancies. In this study 67 primary testicular germ-cell tumors and 4 testicular non-germ-cell malignancies were examined to determine the prevalence and nature of RB gene alterations. Decreased expression of RB gene mRNA was found in all testicular germ-cell tumors (both seminomas and nonseminomas) examined. The RB protein could not be detected by immunohistochemical analysis in the undifferentiated cells of any germ-cell tumors whereas the differentiated malignant cells present in 14/15 teratocarcinomas expressed the protein. No gross alterations of the RB gene were found at DNA level in any of the examined specimens. This and the presence of the RB protein in the more differentiated tumor cells of teratocarcinomas suggest that changes in transcript levels rather than mutation(s) of the gene may be responsible for the absent or decreased RB expression in human germ-cell tumors. To date studies on the mechanism of RB regulation have demonstrated that it occurs at the protein level by phosphorylation of the p105 gene product. The findings presented here indicate that additional regulation might occur at the transcript level.
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