ArticleBMC evolutionary biology2008
Protein evolution of ANTP and PRD homeobox genes.
Article in BMC evolutionary biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 7 citations in OpenAlex.
- Phylum-wide analysis of genes/proteins related to the last steps of assembly and export of extracellular polymeric substances (EPS) in cyanobacteria.Scientific reports · 2015Article
- Classification and expression analyses of homeobox genes from Dictyostelium discoideum.Journal of biosciences · 2015Article
- Article
- A non-tree-based comprehensive study of metazoan Hox and ParaHox genes prompts new insights into their origin and evolution.BMC evolutionary biology · 2010Article
- Gene classification based on amino acid motifs and residues: the DLX (distal-less) test case.PloS one · 2009Article
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Authors and funding
4 authors at 2 institutions in 3 countries.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough homeobox genes have been the subject of many studies, little is known about the main amino acid changes that occurred early in the evolution of genes belonging to different classes.
resultsIn this study, we report a method for the fast and efficient retrieval of sequences belonging to the ANTP (HOXL and NKL) and PRD classes. Furthermore, we look for diagnostic amino acid residues that can be used to distinguish HOXL, NKL and PRD genes.
conclusionThe reported protein features will facilitate the robust classification of homeobox genes from newly sequenced bilaterian genomes. Nevertheless, in non-bilaterian genomes our findings must be cautiously applied. In principle, as long as a good manually curated data set is available the approach here described can be applied to non-bilaterian organisms as well. Our results help focus experimental studies onto investigating the biochemical functions of key homeodomain residues in different gene classes.
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