ReviewNeuroscience and biobehavioral reviews2009
Stress, depression, and coronary artery disease: modeling comorbidity in female primates.
Review in Neuroscience and biobehavioral reviews, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00166114 (Do Antidepressants Reverse the Effects of Early Life Stress on the Brain and Thrombovascular System and Improve Psychological, Neuroendocrine, and Platelet Function), which is not on this map. Cited by 49 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Do Antidepressants Reverse the Effects of Early Life Stress on the Brain and Thrombovascular System and Improve Psychological, Neuroendocrine, and Platelet Function: A Study of Men and Women With Childhood Abuse.
Who cites it
49 citing papers in PubMed, 94 citations in OpenAlex.
- Effects of Classical Music on Behavioral and Physiological Stress Markers in Socially Isolated Prairie Voles.Annals of the New York Academy of Sciences · 2026Article
- Mediterranean vs. Western diet effects on the primate cerebral cortical pre-synaptic proteome: Relationships with the transcriptome and multi-system phenotypes.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Differential effects of Mediterranean vs. Western diets on coronary atherosclerosis and peripheral artery transcriptomics.Frontiers in nutrition · 2025Article
- Prognostic factors of MINOCA and their possible mechanisms.Preventive medicine reports · 2024Review
- The interactive effects of psychosocial stress and diet composition on health in primates.Neuroscience and biobehavioral reviews · 2023Review
- Differential effects of western versus mediterranean diets and psychosocial stress on ovarian function in female monkeys (Macaca fascicularis).Psychoneuroendocrinology · 2023Article
- Mediterranean Diet Reduces Social Isolation and Anxiety in Adult Female Nonhuman Primates.Nutrients · 2022Article
- Psychosocial stress increases risk for type 2 diabetes in female cynomolgus macaques consuming a western diet.Psychoneuroendocrinology · 2022Article
- Evaluating depression- and anxiety-like behaviors in non-human primates.Frontiers in behavioral neuroscience · 2022Review
- Differential paraventricular nucleus activation and behavioral responses to social isolation in prairie voles following environmental enrichment with and without physical exercise.Social neuroscience · 2021Article
- Behavioral and neuroendocrine consequences of disrupting a long-term monogamous social bond in aging prairie voles.Stress (Amsterdam, Netherlands) · 2021Article
- Animal models of human mood.Neuroscience and biobehavioral reviews · 2021Review
- Mediterranean diet, stress resilience, and aging in nonhuman primates.Neurobiology of stress · 2020Article
- Article
- The negative effects of social bond disruption are partially ameliorated by sertraline administration in prairie voles.Autonomic neuroscience : basic & clinical · 2019Article
- Behavioral depression is associated with increased vagally mediated heart rate variability in adult female cynomolgus monkeys (Macaca fascicularis).International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2018Article
- The involvement of free fatty acid-GPR40/FFAR1 signaling in chronic social defeat stress-induced pain prolongation in C57BL/6J male mice.Psychopharmacology · 2018Article
- Long-term sertraline treatment and depression effects on carotid artery atherosclerosis in premenopausal female primates.Menopause (New York, N.Y.) · 2017Article
- Sex-specific effects of stress on metabolic and cardiovascular disease: are women at higher risk?American journal of physiology. Regulatory, integrative and comparative physiology · 2017Review
- Reduced marker of vascularization in the anterior hippocampus in a female monkey model of depression.Physiology & behavior · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Depression and coronary heart disease (CHD) are leading contributors to disease burden in women. CHD and depression are comorbid; whether they have common etiology or depression causes CHD is unclear. The underlying pathology of CHD, coronary artery atherosclerosis (CAA), is present decades before CHD, and the temporal relationship between depression and CAA is unclear. The evidence of involvement of depression in early CAA in cynomolgus monkeys, an established model of CAA and depression, is summarized. Like people, monkeys may respond to the stress of low social status with depressive behavior accompanied by perturbations in hypothalamic-pituitary-adrenal (HPA), autonomic nervous system, lipid metabolism, ovarian, and neural serotonergic system function, all of which are associated with exacerbated CAA. The primate data are consistent with the hypothesis that depression may cause CAA, and also with the hypothesis that CAA and depression may be the result of social stress. More study is needed to discriminate between these two possibilities. The primate data paint a compelling picture of depression as a whole-body disease.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.