ArticleNeuropharmacology2008
Dual neurotoxic and neuroprotective role of metabotropic glutamate receptor 1 in conditions of trophic deprivation - possible role as a dependence receptor.
Article in Neuropharmacology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- Early Effects of the Soluble Amyloid βInternational journal of molecular sciences · 2021Article
- Genetic Deletion of mGlu3 Metabotropic Glutamate Receptors Amplifies Ischemic Brain Damage and Associated Neuroinflammation in Mice.Frontiers in neurology · 2021Article
- Homodimerization enhances both sensitivity and dynamic range of the ligand-binding domain of type 1 metabotropic glutamate receptor.FEBS letters · 2016Article
- Pharmacological characterization of mGlu1 receptors in cerebellar granule cells reveals biased agonism.Neuropharmacology · 2015Article
- Article
- [60]Fullerene derivative modulates adenosine and metabotropic glutamate receptors gene expression: a possible protective effect against hypoxia.Journal of nanobiotechnology · 2014Article
- Article
- Glutamate, glutamate receptors, and downstream signaling pathways.International journal of biological sciences · 2013Review
- Ligand bias at metabotropic glutamate 1a receptors: molecular determinants that distinguish β-arrestin-mediated from G protein-mediated signaling.Molecular pharmacology · 2012Article
- Imaging for metabotropic glutamate receptor subtype 1 in rat and monkey brains using PET with [18F]FITM.European journal of nuclear medicine and molecular imaging · 2012Article
- N-acetylcysteine protects against apoptosis through modulation of group I metabotropic glutamate receptor activity.PloS one · 2012Article
- Heat shock enhances CMV-IE promoter-driven metabotropic glutamate receptor expression and toxicity in transfected cells.Neuropharmacology · 2011Article
- Metabotropic glutamate receptors: from the workbench to the bedside.Neuropharmacology · 2011Review
- The protective signaling of metabotropic glutamate receptor 1 Is mediated by sustained, beta-arrestin-1-dependent ERK phosphorylation.The Journal of biological chemistry · 2010Article
- Triple threat treatment: Exploiting the dependence receptor properties of metabotropic glutamate receptor 1 against melanoma.Molecular & cellular oncologyArticle
- Therapeutic promise and principles: metabotropic glutamate receptors.Oxidative medicine and cellular longevityReview
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Group I metabotropic glutamate receptors have been often implicated in various models of neuronal toxicity, however, the role played by the individual receptors and their putative mechanisms of action contributing to neurotoxicity or neuroprotection remain unclear. Here, using primary cultures of rat cerebellar granule cells and mouse cortical neurons, we show that conditions of trophic deprivation increased mGlu1 expression which correlated with the developing cell death. The inhibition of mGlu1 expression by specific siRNA attenuated toxicity, while adenovirus-mediated overexpression of mGlu1 resulted in increased cell death, indicating a causal relationship between the level of receptor expression and neuronal survival. In pharmacological experiments selective mGlu1 antagonists failed to protect from mGlu1-induced cell death, instead, neuronal survival was promoted by glutamate acting at mGlu1 receptors. Such properties are characteristics of a novel heterogeneous family of dependence receptors which control neuronal apoptosis. Our findings indicate that increased expression of mGlu1 in neurons creates a state of cellular dependence on the presence of its endogenous agonist glutamate. We propose a new role and a new mechanism for mGlu1 action. This receptor may play a crucial role in determining the fate of individual neurons during the development of the nervous system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.