Evidence map›Paper›PMID 18619446›Full record

ArticleGastroenterology2008

Defining disease with laser precision: laser capture microdissection in gastroenterology.

Richard Blatt, Shanthi Srinivasan

Open access · bronzeAbstract read
In one paragraph

Article in Gastroenterology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. ECHOS enables spatial epigenome profiling at subcellular resolution.bioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Muscarinic receptors and ligands in cancer.American journal of physiology. Cell physiology · 2009
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Richard BlattDivision of Digestive Diseases, Emory University, Atlanta, Georgia 30322, USA.
Shanthi Srinivasan
Emory University · US

Funding

Emory Epithelial Pathobiology Research Development CenterR24DK064399 · NIDDK · EMORY UNIVERSITY · PI PARKOS, CHARLES A · 2003 to 2012
$5.3M
Enteric Neuronal Survival in DiabetesK08DK067045 · NIDDK · EMORY UNIVERSITY · PI SRINIVASAN, SHANTHI K · 2004 to 2008
$622k
Role of Oxidative Stress in Diabetic Enteric NeuropathyR03DK078552 · NIDDK · EMORY UNIVERSITY · PI SRINIVASAN, SHANTHI K · 2007 to 2008
$151k
NIDDK NIH HHS DK064399NIDDK NIH HHS K08 DK067045NIDDK NIH HHS KO8 DK067045NIDDK NIH HHS R03 DK078552NIDDK NIH HHS R24 DK064399
6 · The paper itself

Abstract

Laser capture microdissection (LCM) is an efficient and precise method for obtaining pure cell populations or specific cells of interest from a given tissue sample. LCM has been applied to animal and human gastroenterology research in analyzing the protein, DNA, and RNA from all organs of the gastrointestinal system. There are numerous potential applications for this technology in gastroenterology research, including malignancies of the esophagus, stomach, colon, biliary tract, and liver. This technology can also be used to study gastrointestinal infections, inflammatory bowel disease, pancreatitis, motility, malabsorption, and radiation enteropathy. LCM has multiple advantages when compared with conventional methods of microdissection, and this technology can be exploited to identify precursors to disease, diagnostic biomarkers, and therapeutic interventions.

Indexed as

Gastrointestinal DiseasesLasersMicrodissectionAnimalsBiomarkersBiomarkers, TumorGastroenterologyGastrointestinal NeoplasmsGene Expression ProfilingGene Expression RegulationGene Expression Regulation, NeoplasticHumansProteomicsBiomarkersBiomarkers, Tumor

Identifiers

PMID18619446
PMCPMC3736118
OpenAlexW2102713853

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.