ArticleAmerican journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics2009
Genetic predictors of depressive symptoms in cardiac patients.
Article in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Genetic Contributions of Inflammation to Depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Pooled it
- The serotonin transporter promoter variant (5-HTTLPR), stress, and depression meta-analysis revisited: evidence of genetic moderation.Archives of general psychiatry · 2011Pooled it
- Length Polymorphisms in the Angiotensin I-Converting Enzyme Gene and the Serotonin-Transporter-Linked Polymorphic Region Constitute a Risk Haplotype for Depression in Patients with Coronary Artery Disease.Biochemical genetics · 2020Trial
- Proteomic Analysis of the Antidepressant Effects of Shen-Zhi-Ling in Depressed Patients: Identification of Proteins Associated with Platelet Activation and Lipid Metabolism.Cellular and molecular neurobiology · 2018Trial
- Genetic Predictors of Depressive Symptoms in the Look AHEAD Trial.Psychosomatic medicineTrial
- Risk and Resilience Variants in the Retinoic Acid Metabolic and Developmental Pathways Associated with Risk of FASD Outcomes.Biomolecules · 2024Article
- A network medicine-based approach to explore the relationship between depression and inflammation.Frontiers in psychiatry · 2023Article
- Repetitive transcranial direct current stimulation modulates the brain-gut-microbiome axis in obese rodents.Pharmacological reports : PR · 2022Article
- Investigating data-driven biological subtypes of psychiatric disorders using specification-curve analysis.Psychological medicine · 2022Article
- Association of FKBP5 genotype with depressive symptoms in patients with coronary heart disease: a prospective study.Journal of neural transmission (Vienna, Austria : 1996) · 2020Article
- Childhood Adversity Moderates the Effects ofFrontiers in psychiatry · 2019Article
- Depression in people with coronary heart disease: prognostic significance and mechanisms.Current cardiology reports · 2015Review
- Serum proteomic profiling of major depressive disorder.Translational psychiatry · 2015Article
- Article
- [Depression and diabetes mellitus type 2].Der Nervenarzt · 2012Review
- Heartache and heartbreak--the link between depression and cardiovascular disease.Nature reviews. Cardiology · 2012Review
- Gene-environment interactions in geriatric depression.The Psychiatric clinics of North America · 2011Review
- The impact of depression in heart disease.Current psychiatry reports · 2010Review
- Grand challenges in psychosomatic research.Frontiers in psychiatry · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
Abstract
Numerous studies suggest that the prevalence of depression is greater among cardiac patients than in the general population. However, little attention has been paid to the possibility of genetic contributions to depressive symptoms in cardiac patients. We conducted a candidate gene study focusing on genes related to inflammation, platelet aggregation, endothelial function and omega-3 fatty acid metabolism as predictors of depressive symptoms among 977 participants with established cardiovascular disease. Results suggested that genetic variation related to endothelial dysfunction is predictive of depressive symptoms and that endothelial dysfunction may be a novel mechanism contributing to depressive symptoms among cardiac patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.