ArticleInflammatory bowel diseases2009
Fecal calprotectin levels and serological responses to microbial antigens among children and adolescents with inflammatory bowel disease.
Article in Inflammatory bowel diseases, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 4 syntheses or guidelines pooled it, 76 citations in OpenAlex.
- Use of Laboratory Markers in Addition to Symptoms for Diagnosis of Inflammatory Bowel Disease in Children: A Meta-analysis of Individual Patient Data.JAMA pediatrics · 2017Pooled it
- Lower Level ofBioMed research international · 2016Pooled it
- Fecal calprotectin in pediatric inflammatory bowel disease: a systematic review.Digestive diseases and sciences · 2013Pooled it
- Faecal calprotectin for screening of patients with suspected inflammatory bowel disease: diagnostic meta-analysis.BMJ (Clinical research ed.) · 2010Pooled it
- Article
- Fecal calprotectin and other biomarkers are not prospectively associated with food protein-induced allergic proctocolitis.Journal of pediatric gastroenterology and nutrition · 2026Observational
- The gut microbiome and HLA-B27-associated anterior uveitis: a case-control study.Journal of neuroinflammation · 2024Article
- Article
- First-degree Relatives of Celiac Disease Patients Have Increased Seroreactivity to Serum Microbial Markers.Nutrients · 2020Article
- Microbial Biomarkers in Patients with Nonresponsive Celiac Disease.Digestive diseases and sciences · 2018Article
- Clinical Utility of Biomarkers in IBD.Current gastroenterology reports · 2015Review
- Diagnosis of inflammatory bowel disease: Potential role of molecular biometrics.World journal of gastrointestinal surgery · 2014Review
- New serological markers in pediatric patients with inflammatory bowel disease.World journal of gastroenterology · 2014Review
- The role of calprotectin in pediatric disease.BioMed research international · 2013Review
- Article
- Fecal calprotectin is a useful marker for disease activity in pediatric patients with inflammatory bowel disease.Digestive diseases and sciences · 2011Article
- Inflammatory bowel disease unclassified.Journal of Zhejiang University. Science. B · 2011Article
- The role of bacteria and pattern-recognition receptors in Crohn's disease.Nature reviews. Gastroenterology & hepatology · 2011Review
- Current and future role of biomarkers in Crohn's disease risk assessment and treatment.Clinical and experimental gastroenterology · 2011Article
- Noninvasive methods in evaluation of inflammatory bowel disease: where do we stand now? An update.Clinics (Sao Paulo, Brazil) · 2010Review
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundNoninvasive, sensitive, and specific tools for early identification of chronic inflammatory bowel disease (IBD) are needed for clinical practice. The aim was to identify new noninvasive test combinations for characterization of IBD in children and adolescents by comparing serological responses to microbial antigens and fecal calprotectin, a new promising marker for intestinal inflammation.
methodsOur study included 73 children who underwent endoscopies because of suspicion of IBD. Their sera were tested for antibodies to the Pseudomonas fluorescens-associated sequence I2, a Bacteroides caccae TonB-linked outer membrane protein, OmpW, and anti-Saccharomyces cerevisiae (ASCA). Simultaneously, samples for fecal calprotectin measurements were obtained from 55 subjects.
resultsIBD was diagnosed in 60 patients (Crohn's disease [CD] in 18 patients, ulcerative colitis [UC] in 36, and indeterminate colitis [IC] in 6). Thirteen children had a non-IBD disease. Fecal calprotectin levels were elevated (>or=100 microg/g) more frequently in IBD patients (89%, 39/44) compared to non-IBD cases (9%, 1/11, P < 0.001). ASCA antibodies in sera were detected in 67% (12/18) of patients with CD, in 14% (5/36) of the children with UC, and in 50% (3/6) of patients with IC. Seroreactivity for I2 was observed in 42% of the IBD patients, this frequency being higher than in non-IBD cases (7.7% seropositive; P = 0.025). Serum anti-I2 IgA levels (median absorbances) were higher in those with IBD compared to those without gut inflammation (P = 0.039). The combination of the measurements of fecal calprotectin and serological responses to microbial antigens (ASCA, I2, and OmpW) identified 100% of CD patients (sensitivity 100%, specificity 36%, positive predictive value [PPV] 66%, negative predictive value [NPV] 100%) and 89% of UC patients (sensitivity 89%, specificity 36%, PPV 77%, NPV 57%).
conclusionsIncreased levels of serological responses to microbial antigens (ASCA, I2, and OmpW) and fecal calprotectin are evident in both CD and UC patients. The combination of these markers provides valuable, noninvasive tools for the diagnosis of IBD.
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