ArticleClinical and experimental medicine2008
Oxidative stress and protein glycation in primary hypothyroidism. Male/female difference.
Article in Clinical and experimental medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- A meta-analysis of the association of serum ischaemia-modified albumin levels with human hypothyroidism and hyperthyroidism.Bioscience reports · 2017Pooled it
- The hidden phenomenon of oxidative stress during treatment of subclinical-mild hypothyroidism: a protective nutraceutical intervention.Rejuvenation research · 2014Trial
- Protein carbonylation as a modulator of fibrin clot properties in thyroid disorders: impact of therapy.Journal of thrombosis and thrombolysis · 2026Article
- Bidirectional Mendelian randomization and mediation analysis of million-scale data reveal causal relationships between thyroid-related phenotypes, smoking, and lung cancer.Journal of biomedical research · 2025Article
- Hypothyroid women have persistently higher oxidative stress compared to healthy controls.European thyroid journal · 2023Article
- Changes in biomarkers of redox status in serum and saliva of dogs with hypothyroidism.BMC veterinary research · 2023Article
- Are Nutritional Patterns among Polish Hashimoto Thyroiditis Patients Differentiated Internally and Related to Ailments and Other Diseases?Nutrients · 2021Article
- The Level of Zinc, Copper and Antioxidant Status in the Blood Serum of Women with Hashimoto's Thyroiditis.International journal of environmental research and public health · 2021Article
- Muscle fatigue: general understanding and treatment.Experimental & molecular medicine · 2017Review
- Ischemia-modified albumin levels in overt and subclinical hypothyroidism.Journal of endocrinological investigation · 2015Article
- Supplementation of T3 recovers hypothyroid rat liver cells from oxidatively damaged inner mitochondrial membrane leading to apoptosis.BioMed research international · 2014Article
- Association of sympathovagal imbalance with cardiovascular risks in overt hypothyroidism.North American journal of medical sciences · 2013Article
- Levothyroxine and lung cancer in females: the importance of oxidative stress.Reproductive biology and endocrinology : RB&E · 2013Article
- Evaluation of protein oxidation and its association with lipid peroxidation and thyrotropin levels in overt and subclinical hypothyroidism.Endocrine · 2013Article
- Altered fructosamine and lipid fractions in subclinical hypothyroidism.Journal of clinical and diagnostic research : JCDR · 2013Article
- The role of thyroid hormones as inductors of oxidative stress and neurodegeneration.Oxidative medicine and cellular longevity · 2013Review
- Biomarkers of peripheral muscle fatigue during exercise.BMC musculoskeletal disorders · 2012Review
- Association of lipids with oxidative stress biomarkers in subclinical hypothyroidism.International journal of endocrinology · 2012Article
- Evaluating the extent of pregravid risk factors of gestational diabetes mellitus in women in tehran.Iranian Red Crescent medical journal · 2011Article
- Oxidative stress in hypothyroid patients and the role of antioxidant supplementation.Indian journal of endocrinology and metabolismArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oxidative stress (OS) has recently been documented in hypothyroidism, a disease more prevalent in women. In general, OS is reported to be more prevalent in males. However, the effect of gender on OS and protein glycation in hypothyroidism has not been addressed. Blood samples from 37 recently diagnosed primary hypothyroid patients were collected before initiation of thyroxine therapy. Serum glucose, thyroid and lipid profiles were estimated. Glutathione (GSH), malondialdehyde (MDA), protein carbonylation (PCO) and fructosamine levels were analysed. GSH was found to be lower, whereas MDA, fructosamine and PCO levels were higher in male than in female patients. Level of MDA was significantly correlated with fructosamine, protein carbonyls, cholesterol, low-density and high-density lipoprotein cholesterol, triglyceride and GSH in hypothyroid patients. We found OS to be more prevalent in male hypothyroid patients. The positive association of MDA with fructosamine indicates that enhanced lipid peroxidation could be a plausible contributor for accelerated glycation of protein. Considering the negative influence of OS on health, extra attention should be paid to male hypothyroid patients in spite of the low prevalence of this disease in them.
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Registered trials
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